| Literature DB >> 30537506 |
Marc Van den Eynde1, Bernhard Mlecnik2, Gabriela Bindea3, Tessa Fredriksen3, Sarah E Church3, Lucie Lafontaine3, Nacilla Haicheur4, Florence Marliot5, Mihaela Angelova3, Angela Vasaturo3, Daniela Bruni3, Anne Jouret-Mourin6, Pamela Baldin6, Nicolas Huyghe6, Karin Haustermans7, Annelies Debucquoy8, Eric Van Cutsem9, Jean-Francois Gigot6, Catherine Hubert6, Alex Kartheuser6, Christophe Remue6, Daniel Léonard6, Viia Valge-Archer10, Franck Pagès5, Jean-Pascal Machiels6, Jérôme Galon11.
Abstract
Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had a heterogeneous immune infiltrate and mutational diversity. Small metastases had frequently a low Immunoscore and T and B cell score, while a high Immunoscore was associated with a lower number of metastases. Anti-epidermal growth factor receptor treatment modified immune gene expression and significantly increased T cell densities in the metastasis core. The predictive accuracy of the Immunoscore from a single biopsy was superior to the one of programmed cell death ligand 1 (PD-L1). The immune phenotype of the least-infiltrated metastasis had a stronger association with patient outcome than other metastases.Entities:
Keywords: Immunoscore; PDL1; T cells; biopsy; cancer; colorectal cancer; metastasis; prediction; tumor microenvironment; tumor-immunology
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Year: 2018 PMID： 30537506 DOI： 10.1016/j.ccell.2018.11.003
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743