BACKGROUND: Skull base chordomas and chondrosarcomas are rare tumors traditionally treated by surgical resection and adjuvant radiation therapy (RT). We will discuss data evaluating clinical outcomes of proton therapy in the treatment of skull base chordomas and chondrosarcomas. METHODS: A literature review was performed using a MEDLINE search from January 1990 to January 2017. RESULTS: The published data suggest that the dose intensification allowed by proton therapy has resulted in good clinical outcomes and a tolerable toxicity profile. CONCLUSION: Proton therapy is a modern RT technique that has demonstrated improved preliminary clinical outcomes in the treatment of skull base chordomas and chondrosarcomas compared to conventional radiotherapy, and comparable to other advanced photon-based RT techniques.
BACKGROUND: Skull base chordomas and chondrosarcomas are rare tumors traditionally treated by surgical resection and adjuvant radiation therapy (RT). We will discuss data evaluating clinical outcomes of proton therapy in the treatment of skull base chordomas and chondrosarcomas. METHODS: A literature review was performed using a MEDLINE search from January 1990 to January 2017. RESULTS: The published data suggest that the dose intensification allowed by proton therapy has resulted in good clinical outcomes and a tolerable toxicity profile. CONCLUSION: Proton therapy is a modern RT technique that has demonstrated improved preliminary clinical outcomes in the treatment of skull base chordomas and chondrosarcomas compared to conventional radiotherapy, and comparable to other advanced photon-based RT techniques.
Authors: Adam L Holtzman; James E Bates; Christopher G Morris; Michael S Rutenberg; Daniel J Indelicato; Daryoush Tavanaiepour; William M Mendenhall Journal: J Neurol Surg B Skull Base Date: 2021-03-09
Authors: René G C Santegoeds; Mohammed Alahmari; Alida A Postma; Norbert J Liebsch; Damien Charles Weber; Hamid Mammar; Daniëlle B P Eekers; Yasin Temel Journal: Curr Oncol Date: 2022-03-28 Impact factor: 3.109
Authors: Adam L Holtzman; Ronny L Rotondo; Michael S Rutenberg; Daniel J Indelicato; Alexandra De Leo; Dinesh Rao; Jeet Patel; Christopher G Morris; William M Mendenhall Journal: Int J Part Ther Date: 2021-06-25