Jasmine Singh1, William Moore2,3, Farjana Fattah3, Xingya Jiang4, Jie Zheng4, Pamela Kurian3, Muhammad S Beg1,3, Saad A Khan1,3. 1. Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas. 2. Department of Radiology, UT Southwestern Medical Center, Dallas, Texas. 3. UT Southwestern Harold C. Simmons Comprehensive Cancer Center, Department of Pathology, Dallas, Texas. 4. Department of Chemistry and Biochemistry, University of Texas at Dallas, Dallas, Texas.
Abstract
BACKGROUND: Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient. METHODS: Homemade AgNP solution is manufactured using online instructions by a 78-year old male. He started consuming AgNP while on hospice after he developed nasal cavity squamous cell cancer metastatic to liver and lung. RESULTS: Electron microscopy of AgNP solution revealed bimodal nanoparticle size distribution: 3 and 12 nm. Inductively coupled plasma mass spectrometry showed basal silver ion concentrations of 32 ng/g, rising to 46 ng/g 1 hour after ingesting 60 mL of AgNP solution. Urine showed no AgNP. No toxicities were observed and he had complete radiographic resolution of his cancer. He remains without evidence of cancer 18 months later. CONCLUSIONS: AgNP ingestion was associated with sustained radiographic resolution of cancer. Further testing of AgNP should be done to confirm its efficacy in head and neck cancer.
BACKGROUND:Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancerpatient. METHODS: Homemade AgNP solution is manufactured using online instructions by a 78-year old male. He started consuming AgNP while on hospice after he developed nasal cavity squamous cell cancer metastatic to liver and lung. RESULTS: Electron microscopy of AgNP solution revealed bimodal nanoparticle size distribution: 3 and 12 nm. Inductively coupled plasma mass spectrometry showed basal silver ion concentrations of 32 ng/g, rising to 46 ng/g 1 hour after ingesting 60 mL of AgNP solution. Urine showed no AgNP. No toxicities were observed and he had complete radiographic resolution of his cancer. He remains without evidence of cancer 18 months later. CONCLUSIONS:AgNP ingestion was associated with sustained radiographic resolution of cancer. Further testing of AgNP should be done to confirm its efficacy in head and neck cancer.
Authors: Jessica Swanner; Cale D Fahrenholtz; Iliana Tenvooren; Brian W Bernish; James J Sears; Allison Hooker; Cristina M Furdui; Elizabeth Alli; Wencheng Li; George L Donati; Katherine L Cook; Pierre-Alexandre Vidi; Ravi Singh Journal: FASEB Bioadv Date: 2019-09-30
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