BACKGROUND: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. "Compartmental" hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by "en bloc" removal of tumor and its pathways of spread. METHODS: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Group A (n = 35) included naïve patients, and group B (n = 10) recurrent cancers. We evaluated 2-year overall survival (OS), disease-free survival (DFS), local control (LC), and loco-regional control (LRC). RESULTS: Two-year OS, DFS, LC, and LRC were 80%, 91%, 100%, and 94% for group A, and 27%, 26%, 67%, and 36% for group B, respectively. Salvage surgery and positive margins were significantly associated with worse prognosis. CONCLUSION: CHGP is a reliable oncologic approach in primary surgery for advanced OTFMSCC. In recurrent cancers, survival remains poor.
BACKGROUND: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. "Compartmental" hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by "en bloc" removal of tumor and its pathways of spread. METHODS: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Group A (n = 35) included naïve patients, and group B (n = 10) recurrent cancers. We evaluated 2-year overall survival (OS), disease-free survival (DFS), local control (LC), and loco-regional control (LRC). RESULTS: Two-year OS, DFS, LC, and LRC were 80%, 91%, 100%, and 94% for group A, and 27%, 26%, 67%, and 36% for group B, respectively. Salvage surgery and positive margins were significantly associated with worse prognosis. CONCLUSION: CHGP is a reliable oncologic approach in primary surgery for advanced OTFMSCC. In recurrent cancers, survival remains poor.
Authors: Grégoire B Morand; Martina A Broglie; Paul Schumann; Martin W Huellner; Niels J Rupp Journal: Front Oncol Date: 2020-08-27 Impact factor: 6.244
Authors: Alberto Grammatica; Cesare Piazza; Marco Ferrari; Vincenzo Verzeletti; Alberto Paderno; Davide Mattavelli; Alberto Schreiber; Davide Lombardi; Enrico Fazio; Luca Gazzini; Giovanni Giorgetti; Barbara Buffoli; Luigi Fabrizio Rodella; Piero Nicolai; Luca Calabrese Journal: Front Oncol Date: 2021-04-23 Impact factor: 6.244
Authors: Marta Filauro; Francesco Missale; Filippo Marchi; Andrea Iandelli; Andrea Luigi Camillo Carobbio; Francesco Mazzola; Giampiero Parrinello; Emanuele Barabino; Giuseppe Cittadini; Davide Farina; Cesare Piazza; Giorgio Peretti Journal: Eur Arch Otorhinolaryngol Date: 2020-10-21 Impact factor: 2.503