Modeling Heat Transfer in Tumors: A Review of Thermal Therapies.

It is quite challenging to describe heat transfer phenomena in living systems because of the involved phenomena complexity. Indeed, thermal conduction and convection in tissues, blood perfusion, heat generation due to metabolism, complex vascular structure, changing of tissue properties depending on various conditions, are some of the features that make hard to obtain an accurate knowledge of heat transfer in living systems for all the clinical situations. This theme has a key role to predict accurately the temperature distribution in tissues, especially during biomedical applications, such as hyperthermia treatment of cancer, in which tumoral cells have to be destroyed and at the same time the surrounding healthy tissue has to be preserved. Moreover, the lack of experimentation in this field, due to ethical reasons, makes bioheat models even more significant. The first simple bioheat model was developed in 1948 by Pennes (J Appl Physiol 1:93-122, 1948) but it has some shortcomings that make the equation not so accurate. For this reason, over the years it has been modified and more complex models have been developed. The purpose of this review is to give a clear overview of how the bioheat models have been modified when applied in various hyperthermia treatments of cancer.