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Literature DB >> 30535898

Synthesis of benzosuberone-tethered spirooxindoles: 1-3-dipolar cycloaddition of azomethine ylides and arylidene benzosuberones.

Sundaravel Vivek Kumar¹, Gandhi Uma Rani¹, Manohar Divyalakshmi¹, Nattamai Bhuvanesh², Shanmugam Muthusubramanian³, Subbu Perumal⁴.

Abstract

Expedient synthesis of benzosuberone-tethered spirooxindoles was accomplished by a three-component 1,3-dipolar cycloaddition reaction between azomethine ylide (generated in situ) and arylidene benzosuberone. This protocol offers good yield and wide functional group tolerance under mild reaction condition with high regio- and stereoselectivities.

Entities: Chemical

Keywords: 1,3-Dipolar cycloaddition; Azomethine ylide; Benzosuberone; Regioselectivity; Spirooxindoles; Stereoselectivity

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Substances：

Year: 2018 PMID： 30535898 DOI： 10.1007/s11030-018-9901-9

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

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Cited

1 in total

Review 1. Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds.

Authors: Shima Nasri; Mohammad Bayat; Faezeh Mirzaei
Journal: Top Curr Chem (Cham) Date: 2021-05-18

1 in total