| Literature DB >> 30535682 |
Ann-Katrin Kraeuter1,2, Paul C Guest3, Zoltán Sarnyai4,5.
Abstract
The elevated plus maze test is used to measure anxiety-like behavior in rodents. It can be used to gain insight into conditions such as posttraumatic stress disorder (PTSD) and other conditions marked by anxious behavior. It can also be used as a component in screening of novel compounds for anxiolytic properties. This model is based on aversion to open spaces, which is seen as the animal spending more time in the enclosed arms of the maze. This chapter describes the steps necessary for setting up and conducting the test, along with interpretation of the results.Entities:
Keywords: Anxiety; Anxiolytic; Behavior; Elevated plus maze; Mouse; Rodent
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Year: 2019 PMID： 30535682 DOI： 10.1007/978-1-4939-8994-2_4
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745