Nienke de Graeff1, Noortje Groot1,2,3, Paul Brogan4, Seza Ozen5, Tadej Avcin6, Brigitte Bader-Meunier7, Pavla Dolezalova8, Brian M Feldman9, Isabelle Kone-Paut10, Pekka Lahdenne11, Stephen D Marks4, Liza McCann3, Clarissa Pilkington4, Angelo Ravelli12, Annet van Royen1, Yosef Uziel13, Bas Vastert1, Nico Wulffraat1, Sylvia Kamphuis2, Michael W Beresford3,14. 1. Department of Paediatric Rheumatology, Wilhelmina Children's Hospital, Utrecht. 2. Department of Paediatric Rheumatology, Sophia Children's Hospital, Erasmus Medical Centre, Rotterdam, The Netherlands. 3. Department of Paediatric Rheumatology, Alder Hey Children's Hospital, Liverpool. 4. Department of Paediatric Rheumatology, University College London Great Ormond Street Institute of Child Health and Great Ormond St Hospital for Children NHS Foundation Trust, London, UK. 5. Department of Paediatric Rheumatology, Hacettepe University, Ankara, Turkey. 6. Department of Paediatric Rheumatology, University Children's Hospital Ljubljana, Ljubljana, Slovenia. 7. Department of Paediatric Rheumatology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. 8. 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. 9. Department of Paediatric Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, Canada. 10. Department of Paediatric Rheumatology, Bicêtre University Hospital, APHP, University of Paris Sud, Paris, France. 11. Department of Paediatric Rheumatology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. 12. Department of Paediatric Rheumatology, Gaslini Children's Hospital, Genoa, Italy. 13. Meir Medical Center, Kfar Saba, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel. 14. Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Abstract
OBJECTIVES: The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care for children with rheumatic diseases. Systemic vasculitides are very rare in children. Consequently, despite recent advances, paediatric-specific information is sparse. The lack of evidence-based recommendations is an important, unmet need. This study aimed to provide recommendations for diagnosing and treating children with rare forms of childhood systemic vasculitis. METHODS: Recommendations were developed by a consensus process in accordance with the European League Against Rheumatism standard operating procedures. A systematic literature review informed the recommendations, which were devised and evaluated by a panel of experts via an online survey, and two consensus meetings using nominal group technique. Recommendations were accepted when ⩾ 80% of experts agreed. RESULTS: Ninety-three relevant articles were found, and 78 recommendations were accepted in the two consensus meetings. General, cross-cutting recommendations and disease-specific statements regarding the diagnosis and treatment of childhood-onset PAN, granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and Takayasu arteritis are provided. CONCLUSION: These Single Hub and Access point for paediatric Rheumatology in Europe recommendations were formulated through an evidence-based consensus process to support uniform, high-quality standard of care for children with rare forms of paediatric systemic vasculitis.
OBJECTIVES: The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care for children with rheumatic diseases. Systemic vasculitides are very rare in children. Consequently, despite recent advances, paediatric-specific information is sparse. The lack of evidence-based recommendations is an important, unmet need. This study aimed to provide recommendations for diagnosing and treating children with rare forms of childhood systemic vasculitis. METHODS: Recommendations were developed by a consensus process in accordance with the European League Against Rheumatism standard operating procedures. A systematic literature review informed the recommendations, which were devised and evaluated by a panel of experts via an online survey, and two consensus meetings using nominal group technique. Recommendations were accepted when ⩾ 80% of experts agreed. RESULTS: Ninety-three relevant articles were found, and 78 recommendations were accepted in the two consensus meetings. General, cross-cutting recommendations and disease-specific statements regarding the diagnosis and treatment of childhood-onset PAN, granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and Takayasu arteritis are provided. CONCLUSION: These Single Hub and Access point for paediatric Rheumatology in Europe recommendations were formulated through an evidence-based consensus process to support uniform, high-quality standard of care for children with rare forms of paediatric systemic vasculitis.
Authors: Paul Brogan; Rae S M Yeung; Gavin Cleary; Satyapal Rangaraj; Ozgur Kasapcopur; Aimee O Hersh; Suzanne Li; Dusan Paripovic; Kenneth Schikler; Andrew Zeft; Claudia Bracaglia; Despina Eleftheriou; Pooneh Pordeli; Simone Melega; Candice Jamois; Jacques Gaudreault; Margaret Michalska; Paul Brunetta; Jennifer C Cooper; Patricia B Lehane Journal: Arthritis Rheumatol Date: 2021-12-05 Impact factor: 15.483