Adjunctive tadalafil therapy for managing pulmonary hypertension in a patient with obesity hypoventilation syndrome.

Obesity hypoventilation syndrome (OHS) is often associated with pulmonary hypertension (PH), and noninvasive bi-level positive airway pressure therapy is indicated as first-line treatment. However, its effect in reducing pulmonary arterial pressure is insufficient in many cases, thus adjunctive therapies should be evaluated. In this report, we present a patient with OHS-associated PH who was successfully treated by tadalafil in conjunction with weight reduction and bi-level positive airway pressure therapy.