Literature DB >> 3053337

Werner's syndrome associated with malignancies: five case reports with a survey of case histories in Japan.

K Sato1, M Goto, K Nishioka, K Arima, N Hori, N Yamashita, Y Fujimoto, H Nanko, K Ohara, K Ohara.   

Abstract

We present 5 cases of Werner's syndrome associated with malignancies and a survey of 26 cases in the Japanese literature. Though tumors of mesenchymal origin have been reported in Werner's syndrome, 14 of the 31 cases cited in this paper developed carcinomas. Carcinoma of the thyroid gland was relatively high in frequency. The significance of carcinomas in Werner's syndrome should be further investigated.

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Year:  1988        PMID： 3053337     DOI： 10.1159/000212956

Source DB:  PubMed          Journal:  Gerontology        ISSN： 0304-324X            Impact factor:   5.140


  4 in total

1.  Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.

Authors:  P Pichierri; A Franchitto; P Mosesso; F Palitti
Journal:  Mol Biol Cell       Date:  2001-08       Impact factor: 4.138

2.  Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide.

Authors:  Adam Labbé; Ramachander V N Turaga; Eric R Paquet; Chantal Garand; Michel Lebel
Journal:  BMC Genomics       Date:  2010-02-22       Impact factor: 3.969

Review 3.  Soft-tissue mineralization in Werner syndrome.

Authors:  Antonio Leone; Alessandro Maria Costantini; Raffaela Brigida; Onorina Monica Antoniol; Raffaele Antonelli-Incalzi; Lorenzo Bonomo
Journal:  Skeletal Radiol       Date:  2004-05-11       Impact factor: 2.199

4.  A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.

Authors:  M Lebel; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205
  4 in total

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