Heleen Demeyer1,2,3,4, David Donaire-Gonzalez1,2,3, Elena Gimeno-Santos3,5, Maria A Ramon6,7,8, Jordi DE Battle1,6,9, Marta Benet1,2,3, Ignasi Serra1,2,3, Stefano Guerra1,2,3,10, Eva Farrero11,12, Esther Rodriguez6,7,8, Jaume Ferrer6,7,8, Jaume Sauleda13,14, Eduard Monso6,15, Joaquim Gea2,6,16,17, Roberto Rodriguez-Roisin13, Alvar Agusti5,6, Josep M Antó1,2,3,16, Judith Garcia-Aymerich1,2,3. 1. ISGlobal, Barcelona, SPAIN. 2. Universitat Pompeu Fabra (UPF), Barcelona, SPAIN. 3. CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, SPAIN. 4. Department of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, BELGIUM. 5. Respiratory Institute, Hospital Clinic de Barcelona, Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SPAIN. 6. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, SPAIN. 7. Department of Pneumology, Hospital Universitari Vall d'Hebron, Barcelona, SPAIN. 8. Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, SPAIN. 9. Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova i Santa Maria. IRBLLEIDA. Lleida, SPAIN. 10. Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ. 11. Department of Pneumology, Hospital Universitari de Bellvitge, Barcelona, SPAIN. 12. Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, SPAIN. 13. Department Pneumology, Hospital Universitari Son Espases, Palma Mallorca, SPAIN. 14. Institut d'Investigació Sanitària de les Illes Balears (IdISBa), Palma Mallorca, SPAIN. 15. Hospital Universitari Parc Tauli, Sabadell, SPAIN. 16. IMIM (Hospital del Mar Medical Research Institute), Barcelona, SPAIN. 17. Department of Pneumology, Hospital del Mar, Barcelona, SPAIN.
Abstract
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength, and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression. METHODS: We studied 114 COPD patients from the PAC-COPD cohort (94% male, mean [SD], 70 yr [8 yr] of age, 54 [16] forced expiratory volume in 1 s % predicted) at baseline and 2.6 yr (0.6 yr) later. Baseline PA was assessed by accelerometry. Multivariable general linear models were built to assess the association between PA and changes in lung function, functional exercise capacity, muscle strength, health status, and body composition. All models were adjusted for confounders and the respective baseline value of each measure. RESULTS: Per each 1000 steps higher baseline PA, forced expiratory volume in 1 s declined 7 mL less (P < 0.01), forced vital capacity 9 mL less (P = 0.03) and carbon monoxide diffusing capacity 0.10 mL·min·mm Hg less (P = 0.04), while the St George's Respiratory Questionnaire symptom domain deteriorated 0.4 points less (P = 0.03), per year follow-up. Physical activity was not associated with changes in functional exercise capacity, muscle strength, other domains of health status or body composition. CONCLUSIONS: Higher PA is associated with attenuated decline in lung function and reduced health status (symptoms domain) deterioration in moderate-to-very severe COPD patients.
INTRODUCTION:Chronic obstructive pulmonary disease (COPD) progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength, and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression. METHODS: We studied 114 COPDpatients from the PAC-COPD cohort (94% male, mean [SD], 70 yr [8 yr] of age, 54 [16] forced expiratory volume in 1 s % predicted) at baseline and 2.6 yr (0.6 yr) later. Baseline PA was assessed by accelerometry. Multivariable general linear models were built to assess the association between PA and changes in lung function, functional exercise capacity, muscle strength, health status, and body composition. All models were adjusted for confounders and the respective baseline value of each measure. RESULTS: Per each 1000 steps higher baseline PA, forced expiratory volume in 1 s declined 7 mL less (P < 0.01), forced vital capacity 9 mL less (P = 0.03) and carbon monoxide diffusing capacity 0.10 mL·min·mm Hg less (P = 0.04), while the St George's Respiratory Questionnaire symptom domain deteriorated 0.4 points less (P = 0.03), per year follow-up. Physical activity was not associated with changes in functional exercise capacity, muscle strength, other domains of health status or body composition. CONCLUSIONS: Higher PA is associated with attenuated decline in lung function and reduced health status (symptoms domain) deterioration in moderate-to-very severe COPDpatients.
Authors: Heleen Demeyer; Divya Mohan; Chris Burtin; Anouk W Vaes; Matthew Heasley; Russell P Bowler; Richard Casaburi; Christopher B Cooper; Solange Corriol-Rohou; Anja Frei; Alan Hamilton; Nicholas S Hopkinson; Niklas Karlsson; William D-C Man; Marilyn L Moy; Fabio Pitta; Michael I Polkey; Milo Puhan; Stephen I Rennard; Carolyn L Rochester; Harry B Rossiter; Frank Sciurba; Sally Singh; Ruth Tal-Singer; Ioannis Vogiatzis; Henrik Watz; Rob Van Lummel; Jeremy Wyatt; Debora D Merrill; Martijn A Spruit; Judith Garcia-Aymerich; Thierry Troosters Journal: Chronic Obstr Pulm Dis Date: 2021-10-28
Authors: Afroditi K Boutou; Yogini Raste; Heleen Demeyer; Thierry Troosters; Michael I Polkey; Ioannis Vogiatzis; Zafeiris Louvaris; Roberto A Rabinovich; Thys van der Molen; Judith Garcia-Aymerich; Nicholas S Hopkinson Journal: Int J Chron Obstruct Pulmon Dis Date: 2019-09-03