Gauging electrical properties of bone with a bioimpedance-sensing drill.

OBJECTIVE: Multiple surgical procedures require drilling through bone to access underlying anatomy or for device placement. In dental applications, iatrogenic injury caused by accidental perforation of cortical bone into critical anatomy occurs in a significant number of dental implant procedures. Limited real-time sensing methods are available to guide clinicians while drilling through cancellous bone towards cortical interfaces. Early interface detection could prevent accidental damage to underlying anatomic structures. This study aims to demonstrate that electrical impedance spectroscopy can be integrated within a standard surgical drill to distinguish between bone types. APPROACH: A custom bearing and insulated drill bit were designed to collect 10 cortical and cancellous impedance measurements from ex vivo femurs (2 pigs) and 80 bone measurements from in situ femurs (4 pigs). In the in situ study, two return electrodes (simulating a lip-clip and shoulder pad) were used to assess impedance differences associated with return electrode geometry. MAIN
RESULTS: Significant ex vivo differences (p  <  0.05) between cortical and cancellous bone occurred in the real resistivity from 0.1 to 100 kHz and in the imaginary resistivity from 0.3 to 10 kHz, with a maximum cortical-to-cancellous impedance ratio of 1.48. Significant in situ differences (p  <  0.01) were observed in both real and imaginary resistivities from 0.1 to 100 kHz, with a maximum impedance ratio of 2.94. AUCs for classifying bone type based on the real resistivity ranged from 0.84 to 0.96 for ex vivo bone and 0.98 to 1.0 for in situ bone. Mean differences between return electrode geometries were less than 5%. SIGNIFICANCE: The significant cortical-to-cancellous contrast observed indicates this system's potential to provide real-time tissue differentiation during bone drilling procedures.