Literature DB >> 30530604

An IncR Plasmid Harbored by a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Possesses Five Tandem Repeats of the bla KPC-2::NTEKPC-Id Fragment.

Ning Dong1,2, Lizhang Liu1,2, Rong Zhang3, Kaichao Chen1,2, Miaomiao Xie1,2, Edward Wai Chi Chan1,2, Sheng Chen4,2.   

Abstract

Completed sequences of three plasmids from a carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate, SH9, were obtained. In addition to the pLVPK-like virulence-conferring plasmid (pVir-CR-HvKP_SH9), the two multidrug-resistant plasmids (pKPC-CR-HvKP4_SH9 and pCTX-M-CR-HvKP4_SH9) were predicted to originate from a single pKPC-CR-HvKP4-like multireplicon plasmid through homologous recombination. Interestingly, the bla KPC-2 gene was detectable in five tandem repeats exhibiting the format of an NTEKPC-Id-like transposon (IS26-ΔTn3-ISKpn8-bla KPC-2-ΔISKpn6-korC-orf-IS26). The data suggest an important role of DNA recombination in mediating active plasmid evolution.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Klebsiella pneumoniaezzm321990; blaKPC-2zzm321990; cointegration; hypervirulent; tandem repeat

Mesh：

Substances：

Year:  2019        PMID： 30530604      PMCID： PMC6395944          DOI： 10.1128/AAC.01775-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  A Small KPC-2-Producing Plasmid in Klebsiella pneumoniae: Implications for Diversified Vehicles of Carbapenem Resistance.

Authors:  Qiwei Chen; Lizhang Liu; Xiaofang Hu; Xu Jia; Xiaowei Gong; Youjun Feng; Man Huang
Journal:  Microbiol Spectr       Date:  2022-05-17

2.  Epidemiology of Plasmids in Escherichia coli and Klebsiella pneumoniae with Acquired Extended Spectrum Beta-Lactamase Genes Isolated from Chronic Wounds in Ghana.

Authors:  Frederik Pankok; Stefan Taudien; Denise Dekker; Thorsten Thye; Kwabena Oppong; Charity Wiafe Akenten; Maike Lamshöft; Anna Jaeger; Martin Kaase; Simone Scheithauer; Konstantin Tanida; Hagen Frickmann; Jürgen May; Ulrike Loderstädt
Journal:  Antibiotics (Basel)       Date:  2022-05-19

Review 3.  Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives.

Authors:  J E Choby; J Howard-Anderson; D S Weiss
Journal:  J Intern Med       Date:  2019-11-21       Impact factor: 8.989

4.  High Prevalence of 16s rRNA Methylase Genes Among Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Isolates in a Chinese Tertiary Hospital.

Authors:  Wenjian Liao; Liang De Wang; Dan Li; Fang-Ling Du; Dan Long; Yang Liu; OonTek Ng; Wei Zhang
Journal:  Microb Drug Resist       Date:  2020-05-19       Impact factor: 3.431

5.  The Role of Plasmid and Resistance Gene Acquisition in the Emergence of ST23 Multi-Drug Resistant, Hypervirulent Klebsiella pneumoniae.

Authors:  Pengcheng Du; Chao Liu; Shuaihua Fan; Stephen Baker; Jun Guo
Journal:  Microbiol Spectr       Date:  2022-03-17

6.  Hypervirulent Klebsiella pneumoniae is emerging as an increasingly prevalent K. pneumoniae pathotype responsible for nosocomial and healthcare-associated infections in Beijing, China.

Authors:  Chao Liu; Pengcheng Du; Nan Xiao; Fansen Ji; Thomas A Russo; Jun Guo
Journal:  Virulence       Date:  2020-12       Impact factor: 5.882

7.  Detection of a New Resistance-Mediating Plasmid Chimera in a blaOXA-48-Positive Klebsiella pneumoniae Strain at a German University Hospital.

Authors:  Julian Schwanbeck; Wolfgang Bohne; Ufuk Hasdemir; Uwe Groß; Yvonne Pfeifer; Boyke Bunk; Thomas Riedel; Cathrin Spröer; Jörg Overmann; Hagen Frickmann; Andreas E Zautner
Journal:  Microorganisms       Date:  2021-03-31
  7 in total

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