Neuronal identity: the neuron types of a simple chordate sibling, the tadpole larva of Ciona intestinalis.

Neurons of the sparsely populated nervous system of the tadpole larva in the tunicate Ciona intestinalis, a chordate sibling, are known from sporadic previous studies but especially two recent reports that document the connectome of both the central and peripheral nervous systems at EM level. About 330 CNS cells comprise mostly ciliated ependymal cells, with ∼180 neurons that constitute about 50 morphologically distinguishable types. The neurons reveal various chordate characters amid many features that are idiosyncratic. Most neurons are ciliated and lack dendrites, some even lack an axon. Synapses mostly form en passant between axons, and resemble those in basal invertebrates; some are dyads and all have heterogenous synaptic vesicle populations. Each neuron has on average 49 synapses with other cells; these constitute a synaptic network of unpredicted complexity. Crown