Rosário Serrão1, Carmela Piñero2, Jorge Velez3, Daniel Coutinho4, Fernando Maltez5, Sara Lino6, Rui Sarmento E Castro7, Ana Paula Tavares8, Patrícia Pacheco9, Maria João Lopes10, Kamal Mansinho11, Ana Cláudia Miranda12, Isabel Neves13, Ricardo Correia de Abreu14, Joana Almeida15, Leonor Pássaro16. 1. Department of Infectious Diseases, Centro Hospitalar de São João, Porto, Portugal. Electronic address: rosarioserrao@chsj.min-saude.pt. 2. Department of Infectious Diseases, Centro Hospitalar de São João, Porto, Portugal. Electronic address: maria.calvo@chsj.min-saude.pt. 3. Department of Infectious Diseases, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal. Electronic address: 11346@chbv.min-saude.pt. 4. Department of Infectious Diseases, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal. Electronic address: Daniel.Coutinho.18237@chbv.min-saude.pt. 5. Department of Infectious Diseases, Centro Hospitalar Lisboa Central, Hospital Curry Cabral, Lisboa, Portugal. Electronic address: fmaltez@chlc.min-saude.pt. 6. Department of Infectious Diseases, Centro Hospitalar Lisboa Central, Hospital Curry Cabral, Lisboa, Portugal. Electronic address: sara.lino@chlc.min-saude.pt. 7. Department of Infectious Diseases, Centro Hospitalar do Porto, Porto, Portugal. Electronic address: rsarmento@chporto.min-saude.pt. 8. Department of Infectious Diseases, Centro Hospitalar do Porto, Porto, Portugal. Electronic address: anaprat@chporto.min-saude.pt. 9. Department of Infectious Diseases, Hospital Prof. Doutor Fernando Fonseca EPE, Amadora, Portugal. Electronic address: patricia.p.pacheco@hff.min-saude.pt. 10. Department of Infectious Diseases, Hospital Prof. Doutor Fernando Fonseca EPE, Amadora, Portugal. Electronic address: maria.lopes@hff.min-saude.pt. 11. Department of Infectious Diseases, Centro Hospitalar Lisboa Ocidental, Hospital Egas Moniz, Lisboa, Portugal. Electronic address: kmansinho@chlo.min-saude.pt. 12. Department of Infectious Diseases, Centro Hospitalar Lisboa Ocidental, Hospital Egas Moniz, Lisboa, Portugal. Electronic address: amiranda@chlo.min-saude.pt. 13. Department of Infectious Diseases, Unidade Local de Saúde de Matosinhos, Matosinhos, Portugal. Electronic address: isabel.neves@ulsm.min-saude.pt. 14. Department of Infectious Diseases, Unidade Local de Saúde de Matosinhos, Matosinhos, Portugal. Electronic address: correia.abreu@ulsm.min-saude.pt. 15. MSD Lda, Quinta da Fonte, Paço de Arcos, Portugal. Electronic address: joana.almeida@merck.com. 16. MSD Lda, Quinta da Fonte, Paço de Arcos, Portugal. Electronic address: leonor.passaro@merck.com.
Abstract
OBJECTIVE: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. METHODS: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC. RESULTS: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B=0.032, 95% confidence interval 0.015-0.049; p=0.0003) and between the duration of HIV-1 infection and NARC (B=0.039, 95% confidence interval 0.017-0.059; p=0.0005). CONCLUSIONS: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population.
OBJECTIVE: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. METHODS: This was a multicentre, cross-sectional study including HIV-1-infectedpatients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC. RESULTS: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B=0.032, 95% confidence interval 0.015-0.049; p=0.0003) and between the duration of HIV-1 infection and NARC (B=0.039, 95% confidence interval 0.017-0.059; p=0.0005). CONCLUSIONS: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population.
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