Sudhakar George1, Chun Shing Kwok2, Glen P Martin3, Aswin Babu4, Adrian Shufflebotham4, James Nolan4, Karim Ratib4, Rodrigo Bagur5, Mark Gunning4, Mamas Mamas2. 1. The Heart Centre, Royal Stoke Hospital, University Hospital of North Midlands Trust, Stoke-on-Trent, UK. Electronic address: sudhakar.george@uhb.nhs.uk. 2. The Heart Centre, Royal Stoke Hospital, University Hospital of North Midlands Trust, Stoke-on-Trent, UK; Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK. 3. Health e-Research Centre, University of Manchester, Manchester, UK. 4. The Heart Centre, Royal Stoke Hospital, University Hospital of North Midlands Trust, Stoke-on-Trent, UK. 5. Division of Cardiology, London Health Sciences Centre, Department of Medicine, Western University, London, Ontario, Canada.
Abstract
BACKGROUND: Aortic stenosis (AS) is a common valvular abnormality and transcatheter aortic valve implantation (TAVI) is being increasingly used to treat patients considered too high risk for conventional surgery. We aimed to assess the prevalence of comorbid conditions in patients undergoing TAVI using the Charlson Comorbidity Index (CCI) and to assess their impact on clinical and procedural outcomes. METHODS: We analysed 158 patients who underwent a TAVI at our institution between June 2009 and September 2015 to define their co-morbid burden as measured with CCI, and study its impact on procedural characteristics and mortality at 30 days. RESULTS: One hundred fifty-eight (158) patients with a mean age of 82±8years and a mean CCI score of 2.67 underwent a TAVI. Only 12/158 patients had a CCI of 0. The commonest cardiovascular comorbidities were previous myocardial infarction (24%), congestive heart failure (15%) and diabetes mellitus (23%) whilst the commonest non-cardiovascular comorbidities were renal disease (46%) and chronic obstructive pulmonary disease (COPD) (29%). After multivariable adjustment, CCI was not independently associated with adverse clinical outcomes. The addition of CCI to scoring systems such as Logistic EuroScore (LES) and Society of Thoracic Surgeons (STS) risk models improved the area under the curve from 0.75 (95%CI: 0.44-1.00) and 0.83 (95%CI: 0.64-1.00) to 0.78 (95%CI: 0.53-1.00) and 0.89 (95%CI: 0.78-1.00) respectively. CONCLUSIONS: The burden of comorbid conditions in patients undergoing TAVI is significant. The CCI score was not independently associated with a higher risk of death but can be useful in addition to LES and STS risk models in informing decision making on the selection of patients for TAVI.
BACKGROUND:Aortic stenosis (AS) is a common valvular abnormality and transcatheter aortic valve implantation (TAVI) is being increasingly used to treat patients considered too high risk for conventional surgery. We aimed to assess the prevalence of comorbid conditions in patients undergoing TAVI using the Charlson Comorbidity Index (CCI) and to assess their impact on clinical and procedural outcomes. METHODS: We analysed 158 patients who underwent a TAVI at our institution between June 2009 and September 2015 to define their co-morbid burden as measured with CCI, and study its impact on procedural characteristics and mortality at 30 days. RESULTS: One hundred fifty-eight (158) patients with a mean age of 82±8years and a mean CCI score of 2.67 underwent a TAVI. Only 12/158 patients had a CCI of 0. The commonest cardiovascular comorbidities were previous myocardial infarction (24%), congestive heart failure (15%) and diabetes mellitus (23%) whilst the commonest non-cardiovascular comorbidities were renal disease (46%) and chronic obstructive pulmonary disease (COPD) (29%). After multivariable adjustment, CCI was not independently associated with adverse clinical outcomes. The addition of CCI to scoring systems such as Logistic EuroScore (LES) and Society of Thoracic Surgeons (STS) risk models improved the area under the curve from 0.75 (95%CI: 0.44-1.00) and 0.83 (95%CI: 0.64-1.00) to 0.78 (95%CI: 0.53-1.00) and 0.89 (95%CI: 0.78-1.00) respectively. CONCLUSIONS: The burden of comorbid conditions in patients undergoing TAVI is significant. The CCI score was not independently associated with a higher risk of death but can be useful in addition to LES and STS risk models in informing decision making on the selection of patients for TAVI.
Authors: Shubrandu S Sanjoy; Yun-Hee Choi; Robert T Sparrow; Hani Jneid; J Dawn Abbott; Luis Nombela-Franco; Lorenzo Azzalini; David R Holmes; M Chadi Alraies; Islam Y Elgendy; Adrian Baranchuk; Mamas A Mamas; Rodrigo Bagur Journal: J Am Heart Assoc Date: 2021-09-24 Impact factor: 5.501
Authors: Laura Flannery; Muhammad Etiwy; Alexander Camacho; Ran Liu; Nilay Patel; Arpi Tavil-Shatelyan; Varsha K Tanguturi; Jacob P Dal-Bianco; Evin Yucel; Rahul Sakhuja; Arminder S Jassar; Nathaniel B Langer; Ignacio Inglessis; Jonathan J Passeri; Judy Hung; Sammy Elmariah Journal: J Am Heart Assoc Date: 2022-05-27 Impact factor: 6.106