| Literature DB >> 30528778 |
Naoyuki Kurake1, Kenji Ishikawa2, Hiromasa Tanaka3, Hiroshi Hashizume4, Kae Nakamura5, Hiroaki Kajiyama5, Shinya Toyokuni6, Fumitaka Kikkawa6, Masaaki Mizuno7, Masaru Hori8.
Abstract
Non-equilibrium atmospheric pressure plasma (NEAPP) is a mixture of radicals, electrons, anions, cations and light at near body temperature. Plasma-activated medium (PAM) is realized using NEAPP provided by engineered devices and irradiated to a cell culture medium for a period of 600 s. Glioblastoma cells U251SP cultivated in PAM previously indicated that antitumor effects induced PAM-specific apoptotic cell-death. Metabolomic profiles of a hundred intracellular metabolites were analyzed using capillary electrophoresis mass spectrometry. The metabolomic profiles of the PAM-treated U251SP cells were changed significantly with inhibition of the glycolysis pathway and with enhancement of the pentose phosphate pathway.Entities:
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Year: 2018 PMID： 30528778 DOI： 10.1016/j.abb.2018.12.001
Source DB: PubMed Journal: Arch Biochem Biophys ISSN： 0003-9861 Impact factor: 4.013