Shoulong Zhang1, Nuo Wang2, Lei Chen3, Ping Zhang4, Lei Shen5, Shiren Huang6, Chunyang Zhang7, Benqiang Deng8. 1. Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China; Heping Hospital, Shijiazhuang, China. Electronic address: longer_human007@126.com. 2. Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: 724128156@qq.com. 3. Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: gloria_leilei@163.com. 4. Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: pingzhang1121@163.com. 5. Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: doc_shenl@163.com. 6. Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: shir@163.com. 7. Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: zhangli_3954@qq.com. 8. Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: xiaocalf@163.com.
Abstract
BACKGROUND AND PURPOSE: Elevated serum aldosterone concentration is known to be linked with elevated risk of cerebrovascular events as a result of vascular senescence. We studied the association between serum aldosterone concentration and cerebral arteriosclerosis status involving cerebral atherosclerosis burden and cerebral vascular calcification. METHODS: A total of 207 patients (mean age = 62.40 ± 10.54, 70 female patients) admitted with acute ischemic stroke from a single center-based stroke registry were included in the study. The participants were categorized into 4 groups in accordance to the serum aldosterone concentration. Cerebral atherosclerosis burden was derived as the stenosis degree of main intracranial arteries, and cerebral artery calcification was investigated from the cavernous portions of both internal carotid arteries from brain computed tomography angiography. RESULTS: The median aldosterone was 146.00 pg/mL; interquartile range was 133.18-172.10 pg/mL. Advanced intracranial atherosclerosis was present in 134 patients (64.7%) and advanced intracranial arterial calcification was present in 77 patients (37.2%). The prevalence of cerebral atherosclerosis burden and cerebral artery calcification showed increasing tendency through the aldosterone quartiles. Multivariable logistic regression analysis including age, sex, vascular risk factors, estimated glomerular filtration rate and aldosterone quartiles disclosed that the highest serum aldosterone quartile was an independent predictor of advanced intracranial atherosclerosis (odds ratio, 5.07; 95% confidence interval, 1.82-14.17; Ptrend = .001) and advanced intracranial arterial calcification (odds ratio, 6.24; 95% confidence interval, 2.03-19.22; Ptrend = .001). CONCLUSIONS: An increased serum aldosterone concentration was independently associated with intracranial atherosclerosis burden and arterial calcification. Future studies should investigate whether aldosterone antagonists prevent stroke in at risk population.
BACKGROUND AND PURPOSE: Elevated serum aldosterone concentration is known to be linked with elevated risk of cerebrovascular events as a result of vascular senescence. We studied the association between serum aldosterone concentration and cerebral arteriosclerosis status involving cerebral atherosclerosis burden and cerebral vascular calcification. METHODS: A total of 207 patients (mean age = 62.40 ± 10.54, 70 female patients) admitted with acute ischemic stroke from a single center-based stroke registry were included in the study. The participants were categorized into 4 groups in accordance to the serum aldosterone concentration. Cerebral atherosclerosis burden was derived as the stenosis degree of main intracranial arteries, and cerebral artery calcification was investigated from the cavernous portions of both internal carotid arteries from brain computed tomography angiography. RESULTS: The median aldosterone was 146.00 pg/mL; interquartile range was 133.18-172.10 pg/mL. Advanced intracranial atherosclerosis was present in 134 patients (64.7%) and advanced intracranial arterial calcification was present in 77 patients (37.2%). The prevalence of cerebral atherosclerosis burden and cerebral artery calcification showed increasing tendency through the aldosterone quartiles. Multivariable logistic regression analysis including age, sex, vascular risk factors, estimated glomerular filtration rate and aldosterone quartiles disclosed that the highest serum aldosterone quartile was an independent predictor of advanced intracranial atherosclerosis (odds ratio, 5.07; 95% confidence interval, 1.82-14.17; Ptrend = .001) and advanced intracranial arterial calcification (odds ratio, 6.24; 95% confidence interval, 2.03-19.22; Ptrend = .001). CONCLUSIONS: An increased serum aldosterone concentration was independently associated with intracranial atherosclerosis burden and arterial calcification. Future studies should investigate whether aldosterone antagonists prevent stroke in at risk population.
Authors: Marta Kantauskaite; Katharina Bolten; Matthias Boschheidgen; Claudia Schmidt; Thilo Kolb; Kai Uwe Eckardt; Andreas Pasch; Lars Schimmöller; Lars C Rump; Jakob Voelkl; Johannes Stegbauer Journal: Front Cardiovasc Med Date: 2022-01-24