Joachim R Ehrlich1, Christiane Look2, Karel Kostev3, Carsten W Israel4, Andreas Goette5. 1. Medizinische Klinik I, Kardiologie, Angiologie, Pneumologie, St. Josefs-Hospital, Wiesbaden, Germany. Electronic address: jehrlich@joho.de. 2. Sanofi-Aventis Deutschland GmbH, Berlin, Germany. 3. Epidemiology, IQVIA, Frankfurt am Main, Germany. Electronic address: kkostev@de.imshealth.com. 4. Klinik für Innere Medizin - Kardiologie, Diabetologie und Nephrologie, Ev. Klinikum Bethel, Bielefeld, Germany. Electronic address: Carsten.Israel@evkb.de. 5. Medizinische Klinik 2, St. Vincenz Krankenhaus Paderborn, Germany; Working Group: Molekulare Elektrophysiologie, Universitätsklinik Magdeburg, Magdeburg, Germany. Electronic address: andreas.goette@vincenz.de.
Abstract
BACKGROUND: The goal of this study was to analyze the impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation (AF) patients followed in general practices in Germany. METHODS: This study included patients who had received a first prescription of dronedarone, amiodarone, flecainide, propafenone, or sotalol in 1258 general and 62 cardiology practices between January 2010 and March 2017 (index date). The main outcomes of this study were the percentages of patients with myocardial infarction and stroke in the dronedarone group and in the group of individuals who had received other antiarrhythmic drugs within six years of the index date. Cox proportional regression models were used to estimate the relationship between dronedarone and myocardial infarction and stroke. RESULTS: This study included 3498 individuals who had received dronedarone and 17,724 individuals who had received other antiarrhythmic drugs. After six years of follow-up, 3.9% of patients who had received dronedarone and 5.2% of patients who had received other antiarrhythmic drugs had been diagnosed with myocardial infarction (log-rank p-value = 0.002). At the end of the follow-up period, 7.4% of individuals with dronedarone prescriptions and 8.3% of those who had been prescribed other antiarrhythmic drugs had been diagnosed with a stroke (log-rank p-value = 0.003). Dronedarone was associated with a significant decrease in the risk of developing myocardial infarction (HR = 0.78) and suffering a stroke (HR = 0.84) compared to other antiarrhythmics. CONCLUSIONS: In our study, dronedarone was associated with a lower risk of myocardial infarction and stroke in patients with AF compared to other antiarrhythmics.
BACKGROUND: The goal of this study was to analyze the impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation (AF) patients followed in general practices in Germany. METHODS: This study included patients who had received a first prescription of dronedarone, amiodarone, flecainide, propafenone, or sotalol in 1258 general and 62 cardiology practices between January 2010 and March 2017 (index date). The main outcomes of this study were the percentages of patients with myocardial infarction and stroke in the dronedarone group and in the group of individuals who had received other antiarrhythmic drugs within six years of the index date. Cox proportional regression models were used to estimate the relationship between dronedarone and myocardial infarction and stroke. RESULTS: This study included 3498 individuals who had received dronedarone and 17,724 individuals who had received other antiarrhythmic drugs. After six years of follow-up, 3.9% of patients who had received dronedarone and 5.2% of patients who had received other antiarrhythmic drugs had been diagnosed with myocardial infarction (log-rank p-value = 0.002). At the end of the follow-up period, 7.4% of individuals with dronedarone prescriptions and 8.3% of those who had been prescribed other antiarrhythmic drugs had been diagnosed with a stroke (log-rank p-value = 0.003). Dronedarone was associated with a significant decrease in the risk of developing myocardial infarction (HR = 0.78) and suffering a stroke (HR = 0.84) compared to other antiarrhythmics. CONCLUSIONS: In our study, dronedarone was associated with a lower risk of myocardial infarction and stroke in patients with AF compared to other antiarrhythmics.
Authors: Artak Khachatryan; Jose L Merino; Francisco Jose de Abajo; Giovanni L Botto; Paulus Kirchhof; Guenter Breithardt; Bruce Stambler; Lucien Abenhaim; Lamiae Grimaldi-Bensouda Journal: Europace Date: 2022-07-15 Impact factor: 5.486
Authors: Muthiah Vaduganathan; Jonathan P Piccini; A John Camm; Harry J G M Crijns; Stefan D Anker; Javed Butler; John Stewart; Rogelio Braceras; Alessandro P A Albuquerque; Mattias Wieloch; Stefan H Hohnloser Journal: Eur J Heart Fail Date: 2022-04-10 Impact factor: 17.349
Authors: John Marcus Wharton; Jonathan P Piccini; Andrew Koren; Samuel Huse; Christopher J Ronk Journal: J Am Heart Assoc Date: 2022-01-21 Impact factor: 6.106