Marie Trompette1, Laura Le Guilloux1, Laurent Souply2, Bernard Denis2, Ahmed Tsouria1, Hélène Garrec3, Vincent Quentin4, Jacques Vaucel4, Christophe Locher5, Georges Barjonet6, Patrick Marthelet6, Xavier Causse7, Didier Poisson7, Stéphane Nahon8, Caroline Joubrel-Guyot8, Denis Grasset9, Pascal Pouedras9, Christophe Renou10, Anne-Lise Toyer10, Arnaud Boruchowicz11, Christian Cattoen11, Frédéric Heluwaert12, Stéphane Bland12, Roger Faroux13, Valérie Desroys13, Thierry Paupard14, Annick Verhaeghe14, Maria Ortiz Correro15, Charlotte Pujol15, Magali Picon16, Jenny Gallou16, Meddi Kaassi17, Pauline Touroult-Jupin17, Ratmutcho Arotcarena18, Laurent Villeneuve18, Jean-Louis Payen19, Lydie Libier19, Claire Charpignon20, Mahjoub Rahma20, Aude Grébert Manuardi21, Audrey Jeanne21, Pierre Lahmek21, Bertrand Condat3, Gilles Macaigne22. 1. Centre hospitalier de Marne la Vallée, 2-4 cours de la Gondoire, 77600 Jossigny, France. 2. Centre Hospitalier de Colmar, 39, avenue de la Liberté, 68024 Colmar cedex, France. 3. Centre Hospitalier de Bry sur Marne, 2r Pères-Camilliens, 94360 Bry-Sur-Marne, France. 4. Centre hospitalier de Saint-Brieuc, 10, rue Marcel-Proust, 22000 Saint-Brieuc, France. 5. Centre hospitalier de Meaux, 6-8, rue Saint-Fiacre, 77104 Meaux cedex, France. 6. Centre hospitalier de Montelimar, quartier Beausseret, route de Sauzet, 26200 Montélimar, France. 7. Centre hospitalier régional d'Orléans, 14, avenue de l'Hôpital, 45067 Orléans, France. 8. Centre Hospitalier Intercommunal de Montfermeil, 10, rue du Général-Leclerc, 93370 Montfermeil, France. 9. Centre hospitalier de Vannes, 20, boulevard Général-Maurice Guillaudot, 56017 Vannes cedex, France. 10. Centre hospitalier d'Hyères, boulevard Maréchal-Juin, 83400 Hyères, France. 11. Centre hospitalier de Valenciennes, avenue Désandrouin, CS 50479, 59322 Valenciennes cedex, France. 12. Centre hospitalier d'Annecy, 1, avenue de l'Hôpital, 74370 Metz-Tessy, France. 13. Centre hospitalier de la Roche-sur-Yon, boulevard Stéphane-Moreau, 85000 La Roche-sur-Yon, France. 14. Centre hospitalier de Dunkerque, 130, avenue Louis-Herbeaux, 59240 Dunkerque, France. 15. Centre hospitalier régional de Perpignan, 20, avenue du Languedoc, 66000 Perpignan, France. 16. Centre hospitalier d'Aix en Provence, avenue des Tamaris, 13100 Aix-en-Provence, France. 17. Centre hospitalier de Cholet, 1, rue de Marengo, 49300 Cholet, France. 18. Centre Hospitalier de Pau, 4, boulevard Hauterive, 64000 Pau, France. 19. Centre hospitalier de Bayonne, 13, avenue de l'Interne Jacques Loëb, 64100 Bayonne, France. 20. Institut mutualiste montsouris, 42, boulevard Jourdan, 75014 Paris, France. 21. Centre Hospitalier de Villeneuve-Saint-Georges, 40, allée de la Source, 94190 Villeneuve-Saint-Georges, France. 22. Centre hospitalier de Marne la Vallée, 2-4 cours de la Gondoire, 77600 Jossigny, France. Electronic address: gmacaigne@ch-lagny77.fr.
Abstract
INTRODUCTION: In Europe, the number of cases of Campylobacter enteritis and their quinolone resistance is increasing. The aims of this work were to evaluate: (1) the hospital epidemiology of bacterial enteritis between 2010 and 2015. (2) The proportion of Campylobacter and Salmonella enteritis. (3) Resistance to quinolones in adult and paediatric populations. (4) To investigate possible regional epidemiological and bacteriological disparities. PATIENTS AND METHODS: This is a multicentric study carried out in 21 general hospitals (CHG) representing 14 French regions with a prospective collection of the results of coprocultures from 2010 to 2015 in adult and paediatric populations (children < 15 years old not exposed to quinolones). The epidemiological and bacteriological data were collected from software laboratory for positive stool cultures for Campylobacter and Salmonella. The results were compared year by year and by a period of 2 years. RESULTS: In adults, Campylobacter enteritis was each year significantly more frequent than Salmonella (P < 0.001), with a significant increase from 2010 to 2015 (P < 0.05). In children, there was also a significant and stable predominance of Campylobacter enteritis over the study period (P = 0.002). The quinolone resistance of Campylobacter was greater than 50% on the whole territory, with no North-South difference over the three periods studied. It increased significantly from 2012 to 2015 in adults (48% to 55%, P < 0.05) and in children (54% to 61%, P = 0.04). CONCLUSION: Our results confirm the increase in the prevalence of Campylobacter enteritis compared to Salmonella between 2010 and 2015. The quinolone resistance of Campylobacter is greater than 50% on the whole territory, stable between 2010 and 2015 in adults and significantly increased in children.
INTRODUCTION: In Europe, the number of cases of Campylobacter enteritis and their quinolone resistance is increasing. The aims of this work were to evaluate: (1) the hospital epidemiology of bacterial enteritis between 2010 and 2015. (2) The proportion of Campylobacter and Salmonella enteritis. (3) Resistance to quinolones in adult and paediatric populations. (4) To investigate possible regional epidemiological and bacteriological disparities. PATIENTS AND METHODS: This is a multicentric study carried out in 21 general hospitals (CHG) representing 14 French regions with a prospective collection of the results of coprocultures from 2010 to 2015 in adult and paediatric populations (children < 15 years old not exposed to quinolones). The epidemiological and bacteriological data were collected from software laboratory for positive stool cultures for Campylobacter and Salmonella. The results were compared year by year and by a period of 2 years. RESULTS: In adults, Campylobacter enteritis was each year significantly more frequent than Salmonella (P < 0.001), with a significant increase from 2010 to 2015 (P < 0.05). In children, there was also a significant and stable predominance of Campylobacter enteritis over the study period (P = 0.002). The quinolone resistance of Campylobacter was greater than 50% on the whole territory, with no North-South difference over the three periods studied. It increased significantly from 2012 to 2015 in adults (48% to 55%, P < 0.05) and in children (54% to 61%, P = 0.04). CONCLUSION: Our results confirm the increase in the prevalence of Campylobacter enteritis compared to Salmonella between 2010 and 2015. The quinolone resistance of Campylobacter is greater than 50% on the whole territory, stable between 2010 and 2015 in adults and significantly increased in children.