| Literature DB >> 30527395 |
Awaneesh Upadhyay1, Sameer V Dalvi2.
Abstract
Microbubbles are increasingly being used in biomedical applications such as ultrasonic imaging and targeted drug delivery. Microbubbles typically range from 0.1 to 10 µm in size and consist of a protective shell made of lipids or proteins. The shell encapsulates a gaseous core containing gases such as oxygen, sulfur hexafluoride or perfluorocarbons. This review is a consolidated account of information available in the literature on research related to microbubbles. Efforts have been made to present an overview of microbubble synthesis techniques; microbubble stability; microbubbles as contrast agents in ultrasonic imaging and drug delivery vehicles; and side effects related to microbubble administration in humans. Developments related to the modeling of microbubble dissolution and stability are also discussed.Entities:
Keywords: Cancer therapeutic; Contrast enhancement; Dissolution; Immunogenicity; Lipids; Microbubbles; Modeling; Ostwald ripening; Proteins; Stability; Targeted drug delivery
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Year: 2018 PMID： 30527395 DOI： 10.1016/j.ultrasmedbio.2018.09.022
Source DB: PubMed Journal: Ultrasound Med Biol ISSN： 0301-5629 Impact factor: 2.998