Gabriella Serio1, Luigi Vimercati2, Antonio Pennella3, Mattia Gentile4, Domenica Cavone5, Antonia Lucia Buonadonna6, Anna Scattone7, Francesco Fortarezza8, Angela De Palma9, Andrea Marzullo10. 1. Department of Emergency and Organ Transplantation, Pathology Division, University of Bari, Italy. Electronic address: gabriella.serio1@uniba.it. 2. Department of Interdisciplinary Medicine, Occupational Health Division, University of Bari, Italy. Electronic address: luigi.vimercati@uniba.it. 3. Department of Surgery, Pathology Division, University of Foggia, Italy. Electronic address: antonio.pennella@unifg.it. 4. Medical Genetics Division, "Di Venere Hospital", Carbonara, Bari, Italy. Electronic address: mattia.gentile@libero.it. 5. Department of Interdisciplinary Medicine, Occupational Health Division, University of Bari, Italy. Electronic address: domenica.cavone@uniba.it. 6. Medical Genetics Division, "Di Venere Hospital", Carbonara, Bari, Italy. Electronic address: buonadonnal@libero.it. 7. Pathology Division, IRCCS, National Cancer Institute "Giovanni Paolo II", Bari, Italy. Electronic address: annascattoneanatopat@alice.it. 8. Department of Emergency and Organ Transplantation, Pathology Division, University of Bari, Italy. Electronic address: francescofortarezza.md@gmal.com. 9. Department of Emergency and Organ Transplantation, Thoracic Surgery Division, University of Bari, Italy. Electronic address: angela.depalma@uniba.it. 10. Department of Emergency and Organ Transplantation, Pathology Division, University of Bari, Italy. Electronic address: andrea.marzullo@uniba.it.
Abstract
INTRODUCTION: Malignant mesothelioma is an aggressive malignancy of the thoracic cavity caused by prior asbestos exposure. In the peritoneum the mesothelioma is an extremely rare condition. In the present preliminary study, high-resolution array-comparative genomic hybridization (a-CGH) was performed to identify genetic imbalances in a series of malignant peritoneal mesothelioma cases. MATERIALS AND METHODS: Between 1990 and 2008, among the cases recorded in the Apulia Mesothelioma Register, we found 22 peritoneal mesothelioma cases. CGH-array was performed on samples from all patients. RESULTS: The CGH-array analysis revealed multiple chromosomal imbalances. Interestingly, deletion at 8p23.1 was observed in 12 cases. Furthermore, another novel deletion at 1q21 was present in 11. Often, 1q21 and 8p23.1 losses were present in the same patient (7 cases). Losses of BAP1 and CDKN2A loci were not detected. DISCUSSION: The region at 8p23.1 contains the beta-defensin gene cluster (DEF) and 1q21 contains ubiquitin conjugating enzyme E2 (UBE2Q1). We hypotesized that the loss of function of ubiquitination, as well as of the defensins, could play an important role in the initial development and subsequent progression of mesothelioma.
INTRODUCTION:Malignant mesothelioma is an aggressive malignancy of the thoracic cavity caused by prior asbestos exposure. In the peritoneum the mesothelioma is an extremely rare condition. In the present preliminary study, high-resolution array-comparative genomic hybridization (a-CGH) was performed to identify genetic imbalances in a series of malignant peritoneal mesothelioma cases. MATERIALS AND METHODS: Between 1990 and 2008, among the cases recorded in the Apulia Mesothelioma Register, we found 22 peritoneal mesothelioma cases. CGH-array was performed on samples from all patients. RESULTS: The CGH-array analysis revealed multiple chromosomal imbalances. Interestingly, deletion at 8p23.1 was observed in 12 cases. Furthermore, another novel deletion at 1q21 was present in 11. Often, 1q21 and 8p23.1 losses were present in the same patient (7 cases). Losses of BAP1 and CDKN2A loci were not detected. DISCUSSION: The region at 8p23.1 contains the beta-defensin gene cluster (DEF) and 1q21 contains ubiquitin conjugating enzyme E2 (UBE2Q1). We hypotesized that the loss of function of ubiquitination, as well as of the defensins, could play an important role in the initial development and subsequent progression of mesothelioma.
Authors: Luigi Vimercati; Domenica Cavone; Maria Celeste Delfino; Luigi De Maria; Antonio Caputi; Giovanni Maria Ferri; Gabriella Serio Journal: Environ Health Date: 2019-08-30 Impact factor: 5.984
Authors: Luigi Vimercati; Domenica Cavone; Maria Celeste Delfino; Biagio Bruni; Luigi De Maria; Antonio Caputi; Stefania Sponselli; Roberta Rossi; Leonardo Resta; Francesco Fortarezza; Federica Pezzuto; Gabriella Serio Journal: Cancers (Basel) Date: 2021-05-10 Impact factor: 6.639
Authors: Luigi De Maria; Caterina Ledda; Antonio Caputi; Francesca Mansi; Enza Sabrina Silvana Cannone; Stefania Sponselli; Domenica Cavone; Francesco Birtolo; Emanuele Cannizzaro; Giovanni Maria Ferri; Venerando Rapisarda; Luigi Vimercati Journal: Front Public Health Date: 2020-07-17
Authors: Luigi Vimercati; Lucia Bisceglia; Domenica Cavone; Antonio Caputi; Luigi De Maria; Maria Celeste Delfino; Vincenzo Corrado; Giovanni Maria Ferri Journal: Int J Environ Res Public Health Date: 2020-03-25 Impact factor: 3.390
Authors: Luigi Vimercati; Luigi De Maria; Antonio Caputi; Enza Sabrina Silvana Cannone; Francesca Mansi; Domenica Cavone; Paolo Romita; Giuseppe Argenziano; Alessandro Di Stefani; Aurora Parodi; Ketty Peris; Massimiliano Scalvenzi; Giampiero Girolomoni; Caterina Foti Journal: Int J Environ Res Public Health Date: 2020-03-30 Impact factor: 3.390