| Literature DB >> 30526675 |
Morris Freedman1,2,3,4,5, Larry Leach6,7, M Carmela Tartaglia8,6,9,10, Kathryn A Stokes11, Yael Goldberg11, Robyn Spring12, Nima Nourhaghighi6,13, Tom Gee12, Stephen C Strother12,6,14, Mohammad O Alhaj11,15, Michael Borrie16,17, Sultan Darvesh18, Alita Fernandez11, Corinne E Fischer6,19,20, Jennifer Fogarty16,17, Barry D Greenberg6,21, Michelle Gyenes11, Nathan Herrmann6,13,22,20, Ron Keren6,21,20, Josh Kirstein11, Sanjeev Kumar6,20,23, Benjamin Lam8,22,24, Suvendrini Lena8,6,23, Mary Pat McAndrews9,25,26, Gary Naglie11,12,6,27, Robert Partridge9, Tarek K Rajji6,20,23,28, William Reichmann11,6,20, M Uri Wolf11,6,20, Nicolaas P L G Verhoeff11,6,20, Jordana L Waserman11, Sandra E Black8,6,13,22,24,29, David F Tang-Wai8,6,9,23,25.
Abstract
Upon publication of this article [1], it was brought to our attention that one of the 303 participants in the normative study should have been deleted from the database.Entities:
Year: 2018 PMID: 30526675 PMCID: PMC6286597 DOI: 10.1186/s13195-018-0446-z
Source DB: PubMed Journal: Alzheimers Res Ther Impact factor: 6.982
Toronto Cognitive Assessment (TorCA) group profiles and normative data
| Group profile | Age group | ||||||
|---|---|---|---|---|---|---|---|
| 50–89 years | 50–59 years | 60–69 years | 70–79 years | 80–89 years | |||
|
| 302 | 75 | 77 | 75 | 75 | ||
| Male/female | 103/199 | 28/47 | 22/55 | 20/55 | 33/42 | ||
| Years of education, median (range) | 16 (8–20) | 16 (12–20) | 16 (11–20) | 16 (9–20) | 14 (8–20) | ||
| TorCA Sum Index, mean (standard deviation) | 292.8 (18.4) | 297.6 (18.6) | 296.9 (16.7) | 290.5 (16.6) | 286.0 (19.4) | ||
| TorCA Sum Index, median | 295 | 301 | 298 | 291 | 289 | ||
| Normative Data | Percentile range | Rating | 50–89 years | 50–59 years | 60–69 years | 70–79 years | 80–89 years |
| Sum Index | ≤ 5 | Impaired | < 261 | < 266 | < 272 | < 262 | < 257 |
| 6–24 | Borderline | 261–281 | 266–287 | 272–287 | 262–280 | 257–272 | |
| ≥ 25 | Normal limits | > 281 | > 287 | > 287 | > 280 | > 272 | |
| Orientation | ≤ 5 | Impaired | < 10 | < 10 | < 10 | < 10 | < 10 |
| 6–24 | Borderline | 10 | 10 | 10 | 10 | 10 | |
| ≥ 25 | Normal limits | > 10 | > 10 | > 10 | > 10 | > 10 | |
| Immediate Memory Recall | ≤ 5 | Impaired | < 15 | < 17 | < 16 | < 15 | < 14 |
| 6–24 | Borderline | 15–18 | 17–20 | 16–18 | 15–17 | 14–16 | |
| ≥ 25 | Normal limits | > 18 | > 20 | > 18 | > 17 | > 16 | |
| Delayed Memory Recall | ≤ 5 | Impaired | < 10 | < 14 | < 12 | < 8 | < 6 |
| 6–24 | Borderline | 10–14 | 14–16 | 12–15 | 8–12 | 6–12 | |
| ≥ 25 | Normal limits | > 14 | > 16 | > 15 | > 12 | > 12 | |
| Delayed Memory Recognition | ≤ 5 | Impaired | < 19 | < 20 | < 19 | < 18 | < 18 |
| 6–24 | Borderline | 19 | 20 | 19 | 18–19 | 18 | |
| ≥ 25 | Normal limits | > 19 | 21 | > 19 | > 19 | > 18 | |
| Visuospatial | ≤ 5 | Impaired | < 25 | < 27 | < 25 | < 24 | < 24 |
| 6–24 | Borderline | 25–27 | 27–28 | 25–27 | 24–27 | 24–27 | |
| ≥ 25 | Normal limits | > 27 | > 28 | > 27 | > 27 | > 27 | |
| Working Memory/Attention/Executive Control | ≤ 5 | Impaired | < 99 | < 98 | < 102 | < 99 | < 98 |
| 6–24 | Borderline | 99–106 | 98–105 | 102–107 | 99–106 | 98–105 | |
| ≥ 25 | Normal limits | > 106 | > 105 | > 107 | > 106 | > 105 | |
| Language | ≤ 5 | Impaired | < 71 | < 63 | < 74 | < 74 | < 66 |
| 6–24 | Borderline | 71–78 | 63–78 | 74–80 | 74–78 | 66–76 | |
| ≥ 25 | Normal limits | > 78 | > 78 | > 80 | > 78 | > 76 | |
Normative data for subtests within domains: Visuospatial
| Toronto Cognitive Assessment Visuospatial test ratings | |||
|---|---|---|---|
| Percentile | Rating | Benson Figure Copy | Clock Drawing |
| Ages 50–89 years | |||
| ≤ 5 | Below normal | < 14 | < 10 |
| 6–24 | Borderline | 14 | 10–12 |
| ≥ 25 | Within normal limits | > 14 | > 12 |
| Ages 50–59 years | |||
| ≤ 5 | Below normal | < 15 | < 11 |
| 6–24 | Borderline | 15 | 11–12 |
| ≥ 25 | Within normal limits | > 15 | > 12 |
| Ages 60–69 years | |||
| ≤ 5 | Below normal | < 14 | < 10 |
| 6–24 | Borderline | 14 | 10–12 |
| ≥ 25 | Within normal limits | > 14 | > 12 |
| Ages 70–79 years | |||
| ≤ 5 | Below normal | < 14 | < 10 |
| 6–24 | Borderline | 14 | 10–12 |
| ≥ 25 | Within normal limits | > 14 | > 12 |
| Ages 80–89 years | |||
| ≤ 5 | Below normal | < 13 | < 9 |
| 6–24 | Borderline | 13–14 | 9–12 |
| ≥ 25 | Within normal limits | > 14 | > 12 |
Normative data for subtests within domains: Working Memory/Attention/Executive Control
| Toronto Cognitive Assessment Working Memory/Attention/Executive Control Test Ratings | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Percentile | Rating | Serial Subtractions 7 s | Serial Subtractions 3 s | Serial Subtractions Total | Digit Span Forwards | Digit Span Backwards | Digit Span Total | Trails A Time | Trails A Score | Trails B Time | Trails B Score | Trails Time Difference | Alternating Sequences | Similarities |
| Ages 50–89 years | ||||||||||||||
| ≤ 5 | Below normal | < 9 | < 11 | < 21 | < 5 | < 4 | < 10 | > 67 | < 24 | > 163 | < 22 | > 107 | < 2 | < 7 |
| 6–24 | Borderline | 9–10 | 11–12 | 21–23 | 5 | 4 | 10 | 67–47 | – | 163–107 | 22 | 107–63 | – | 7–8 |
| ≥ 25 | Within normal limits | > 10 | > 12 | > 23 | > 5 | > 4 | > 10 | < 47 | 24 | < 107 | > 22 | < 63 | 2 | > 8 |
| Ages 50–59 years | ||||||||||||||
| ≤ 5 | Below normal | < 9 | < 11 | < 21 | < 5 | < 4 | < 10 | > 67 | < 24 | > 163 | < 22 | > 107 | < 2 | < 7 |
| 6–24 | Borderline | 9–10 | 11–12 | 21–23 | 5 | 4 | 10 | 67–47 | – | 163–107 | 22 | 107–63 | – | 7–8 |
| ≥ 25 | Within normal limits | > 10 | > 12 | > 23 | > 5 | > 4 | > 10 | < 47 | 24 | < 107 | > 22 | < 63 | 2 | > 8 |
| Ages 60–69 years | ||||||||||||||
| ≤ 5 | Below normal | < 10 | < 11 | < 21 | < 5 | < 4 | < 9 | > 59 | < 24 | > 146 | < 24 | > 100 | < 2 | < 9 |
| 6–24 | Borderline | 10 | 11–12 | 21–23 | 5 | 4 | 9–10 | 59–43 | – | 146–91 | – | 100–53 | – | 9 |
| ≥ 25 | Within normal limits | > 10 | > 12 | > 23 | > 5 | > 4 | > 10 | < 43 | 24 | < 91 | 24 | < 53 | 2 | > 9 |
| Ages 70–79 years | ||||||||||||||
| ≤ 5 | Below normal | < 9 | < 11 | < 20 | < 5 | < 4 | < 10 | > 86 | < 24 | > 196 | < 23 | > 137 | 0 | < 8 |
| 6–24 | Borderline | 9–11 | 11 | 20–23 | 5 | 4 | 10 | 86–49 | – | 196–111 | 23 | 137–65 | 1 | 8 |
| ≥ 25 | Within normal limits | > 11 | > 11 | > 23 | > 5 | > 4 | > 10 | < 49 | 24 | < 111 | 24 | < 65 | 2 | > 8 |
| Ages 80–89 years | ||||||||||||||
| ≤ 5 | Below normal | < 9 | < 11 | < 22 | < 5 | < 4 | < 9 | > 73 | < 24 | > 198 | < 21 | > 159 | 0 | < 7 |
| 6–24 | Borderline | 9–10 | 11–12 | 22–23 | 5 | 4 | 9 | 73–53 | – | 198–120 | 21–22 | 159–85 | 1 | 7–8 |
| ≥ 25 | Within normal limits | > 10 | > 12 | > 23 | > 5 | > 4 | > 9 | < 53 | 24 | < 120 | > 22 | < 85 | 2 | > 8 |
Normative data for subtests within domains: Language
| Toronto Cognitive Assessment Language Test Ratings: | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Percentile | Rating | F-words | Animal names | Naming | Repetition | Single word comprehension | Reading single word comprehension | Sentence comprehension | Single word reading | Semantic knowledge |
| Ages 50–89 years | ||||||||||
| ≤ 5 | Below normal limits | < 10 | < 14 | < 13 | < 8 | < 8 | < 2 | < 5 | < 11 | < 9 |
| 6–24 | Borderline | 10–12 | 14–16 | 13 | 8 | – | – | 5–6 | 11 | 9 |
| ≥ 25 | Normal limits | > 12 | > 16 | > 13 | > 8 | 8 | 2 | > 6 | 12 | > 9 |
| Ages 50–59 years | ||||||||||
| ≤ 5 | Below normal limits | < 8 | < 13 | < 9 | < 5 | < 8 | < 2 | < 5 | < 9 | < 9 |
| 6–24 | Borderline | 8–11 | 13–18 | 9–13 | 5–7 | – | – | 5–6 | 9–11 | 9 |
| ≥ 25 | Normal limits | > 11 | > 18 | > 13 | > 7 | 8 | 2 | > 6 | 12 | 10 |
| Ages 60–69 years | ||||||||||
| ≤ 5 | Below normal limits | < 10 | < 14 | < 13 | < 8 | < 8 | < 2 | < 6 | < 12 | < 9 |
| 6–24 | Borderline | 10–12 | 14–17 | 13 | 8 | – | – | 6–7 | – | 9 |
| ≥ 25 | Normal limits | > 12 | > 17 | > 13 | > 8 | 8 | 2 | 8 | 12 | 10 |
| Ages 70–79 years | ||||||||||
| ≤ 5 | Below normal limits | < 10 | < 14 | < 13 | < 8 | < 8 | < 2 | < 5 | < 12 | < 9 |
| 6–24 | Borderline | 10–12 | 14–16 | 13 | 8 | – | – | 5–6 | – | 9 |
| ≥ 25 | Normal limits | > 12 | > 16 | > 13 | > 8 | 8 | 2 | > 6 | 12 | 10 |
| Ages 80–89 years | ||||||||||
| ≤ 5 | Below normal limits | < 11 | < 11 | < 12 | < 8 | < 8 | < 2 | < 4 | < 11 | < 9 |
| 6–24 | Borderline | 11–12 | 11–15 | 12 | 8 | – | – | 4–5 | 11 | 9 |
| ≥ 25 | Normal limits | > 12 | > 15 | > 12 | > 8 | 8 | 2 | > 5 | 12 | 10 |
Toronto Cognitive Assessment (TorCA) Test–Retest Results
| TorCA index | Test 1 mean (SE) | Test 2 mean (SE) | Test 2–Test 1 mean difference (SED) | Stability ( | % change | |
|---|---|---|---|---|---|---|
| Orientation | 11.2 ± 0.2 | 11.3 ± 0.2 | 0.1 ± 0.2 | 0.5 (0.631) | 0.10 | 0.1 |
| Memory—Immediate Recall | 19.5 ± 0.7 | 21.9 ± 0.7 | 2.4 ± 0.5 | 4.6 | 0.73 | 14.3 |
| Memory—Delayed Recall | 15.8 ± 0.9 | 17.5 ± 0.8 | 1.7 ± 0.5 | 3.4 | 0.83 | 10.7 |
| Memory—Delayed Recognition | 20.2 ± 0.2 | 20.4 ± 0.2 | 0.2 ± 0.2 | 0.9 | 0.57 | 1.0 |
| Visuospatial | 28.6 ± 0.4 | 28.4 ± 0.4 | − 0.2 ± 0.3 | − 0.7 | 0.68 | 0.7 |
| Executive Controla | 111.0 ± 1.2 | 112.0 ± 1.3 | 1.0 ± 1.3 | 0.9 | 0.52 | 1.0 |
| Language | 84.4 ± 1.3 | 83.1 ± 1.3 | − 1.3 ± 0.9 | − 1.4 | 0.75 | 1.5 |
| Sum | 290.7 ± 3.2 | 294.0 ± 3.4 | 3.3 ± 1.4 | 2.4 | 0.92 | 1.1 |
Test 1 and Test 2 mean indices and test–retest correlations (test stability) expressed as Pearson r
Interpretation of stability coefficients (Pearson r): very good, ≥ 0.90; good, 0.80–0.89; acceptable, 0.70–0.79; low, < 0.70
SE standard error, SED standard error of the difference
aWorking Memory/Attention/Executive Control
Normal cognition and aMCI group demographics and TorCA indices comparisons
| Group demographics | NC | aMCI | ||
| | 57 | 50 | ||
| Male/female | 19/38 | 27/23 | ||
| Age, mean (SD) | 75.3 (7.9) | 77.7 (6.5) | ||
| Years of education, mean (SD) | 15.02 (3.2) | 15.5 (3.4) | ||
| IQ, mean (SD) | 122.81 (13.54)* | 121.33 (13.98) | ||
| TorCA index group comparisons | NC (SD) | aMCI (SD) | Effect size, Hedge’s | |
| Orientation | 11.58 (0.76) | 10.38 (1.69) | 4.84 | − 0.93 |
| Memory—Immediate Recall | 20.77 (4.45) | 14.18 (3.29) | 8.62 | − 1.66 |
| Memory—Delayed Recall | 16.86 (4.85) | 6.66 (4.65) | 11.07 | − 2.13 |
| Memory—Delayed Recognition | 20.19 (1.33) | 17.42 (2.42) | 7.45 | −1.43 |
| Visuospatial | 29.79 (1.80) | 30.02 (2.16) | 0.602 | 0.12 |
| Working Memory/Attention/Executive Control | 108.47 (10.30) | 107.34 (8.17) | 0.625 | − 0.12 |
| Language | 80.16 (8.34) | 76.90 (6.23) | 2.26 | − 0.42 |
| Sum | 287.82 (23.92) | 262.86 (17.63) | 6.07 | − 1.17 |
aMCI amnestic mild cognitive impairment, CI confidence interval, NC normal cognition, SD standard deviation, TorCA Toronto Cognitive Assessment
*One participant with aMCI was not given the verbal component of the IQ estimate due to non-exclusionary English as a second language considerations. A comparable estimate of IQ was within the range exhibited by the remaining aMCI participants
**Significance tests corrected for multiple comparisons using Bonferroni correction at p ≤ 0.05/7 (0.007)