| Literature DB >> 30526407 |
Ellen Wilhelmina van Geffen1, Arjan Petrus Maria van Caam1, Elly Louise Vitters1, Henk Maria van Beuningen1, Fons Adrianus van de Loo1, Peter Leonardus Everardus Maria van Lent1, Marije Ingrid Koenders1, Peter Mario van der Kraan1.
Abstract
IMPACT STATEMENT: Catabolic factors present in a damaged joint inhibit chondrogenic differentiation of mesenchymal stem cells, thereby reducing the chance for successful cartilage formation. By improving stem cell-based cartilage repair with interleukin-37 (IL37), we might be able to inhibit the worsening progression of focal cartilage defects and prevent further development of joint diseases such as osteoarthritis. This will avoid chronic pain and impaired joint mobility for patients and reduce costs for society.Entities:
Keywords: IL1β; IL37; cartilage formation; mesenchymal stem cells; osteoarthritis
Mesh：
Substances：
Year: 2019 PMID： 30526407 DOI： 10.1089/ten.TEA.2018.0267
Source DB: PubMed Journal: Tissue Eng Part A ISSN： 1937-3341 Impact factor: 3.845