Stefano Magon1,2, Arne May3, Anne Stankewitz3,4, Peter J Goadsby5,6, Christoph Schankin7, Messoud Ashina8, Faisal M Amin8, Christian L Seifert4, M Mallar Chakravarty9,10, Jannis Müller1, Till Sprenger1,11. 1. 1 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland. 2. 2 Medical Image Analysis Center, University Hospital Basel, University of Basel, Basel, Switzerland. 3. 3 Institute for Systems Neuroscience, University of Hamburg, Hamburg, Germany. 4. 4 Department of Neurology, Technische Universität Muenchen, Munich, Germany. 5. 5 Headache Group-Department of Neurology, University of California, San Francisco, CA, USA. 6. 6 NIHR-Wellcome Trust King's Clinical Research Facility, King's College London, London, UK. 7. 7 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. 8. 8 Danish Headache Center and Department of Neurology, University of Copenhagen, Copenhagen, Denmark. 9. 9 Cerebral Imaging Centre, Douglas Mental Health University Institute Montreal, Montreal, Quebec, Canada. 10. 10 Department of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada. 11. 11 Department of Neurology, DKD HELIOS Klinik Wiesbaden, Wiesbaden, Germany.
Abstract
BACKGROUND: Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies. OBJECTIVE: To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort. METHODS: Three Tesla MRI data of 131 patients (38 with and 93 without aura) and 115 control subjects were analysed. A vertex-wise linear model was applied controlling for age, gender and MRI scanner to investigate differences between groups and determine the impact of clinical factors on cortical thickness measures. RESULTS: Migraineurs showed areas of thinned cortex compared with controls bilaterally in the central sulcus, in the left middle-frontal gyrus, in left visual cortices and the right occipito-temporal gyrus. Frequency of migraine attacks and the duration of the disorder had a significant impact on cortical thickness in the sensorimotor cortex and middle-frontal gyrus. Patients without aura showed thinner cortex than controls bilaterally in the central sulcus and in the middle frontal gyrus, in the left primary visual cortices, in the left supramarginal gyrus and in the right cuneus. Patients with aura showed clusters of thinner cortex bilaterally in the subparietal sulcus (between the precuneus and posterior cingulate cortex), in the left intraparietal sulcus and in the right anterior cingulate. CONCLUSION: These results indicate cortical abnormalities in specific brain regions in migraineurs. Some of the observed abnormalities may reflect a genetic susceptibility towards developing migraine attacks, while others are probably a consequence of repeated head pain attacks.
BACKGROUND: Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies. OBJECTIVE: To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort. METHODS: Three Tesla MRI data of 131 patients (38 with and 93 without aura) and 115 control subjects were analysed. A vertex-wise linear model was applied controlling for age, gender and MRI scanner to investigate differences between groups and determine the impact of clinical factors on cortical thickness measures. RESULTS:Migraineurs showed areas of thinned cortex compared with controls bilaterally in the central sulcus, in the left middle-frontal gyrus, in left visual cortices and the right occipito-temporal gyrus. Frequency of migraine attacks and the duration of the disorder had a significant impact on cortical thickness in the sensorimotor cortex and middle-frontal gyrus. Patients without aura showed thinner cortex than controls bilaterally in the central sulcus and in the middle frontal gyrus, in the left primary visual cortices, in the left supramarginal gyrus and in the right cuneus. Patients with aura showed clusters of thinner cortex bilaterally in the subparietal sulcus (between the precuneus and posterior cingulate cortex), in the left intraparietal sulcus and in the right anterior cingulate. CONCLUSION: These results indicate cortical abnormalities in specific brain regions in migraineurs. Some of the observed abnormalities may reflect a genetic susceptibility towards developing migraine attacks, while others are probably a consequence of repeated head pain attacks.
Entities:
Keywords:
Migraine; brain; cortical thickness; magnetic resonance imaging
Authors: Zachariah Bertels; Harinder Singh; Isaac Dripps; Kendra Siegersma; Alycia F Tipton; Wiktor D Witkowski; Zoie Sheets; Pal Shah; Catherine Conway; Elizaveta Mangutov; Mei Ao; Valentina Petukhova; Bhargava Karumudi; Pavel A Petukhov; Serapio M Baca; Mark M Rasenick; Amynah A Pradhan Journal: Elife Date: 2021-04-15 Impact factor: 8.140
Authors: Katarzyna Malgorzata Kwiatkowska; Maria Giulia Bacalini; Claudia Sala; Helena Kaziyama; Daniel Ciampi de Andrade; Rossana Terlizzi; Giulia Giannini; Sabina Cevoli; Giulia Pierangeli; Pietro Cortelli; Paolo Garagnani; Chiara Pirazzini Journal: Front Public Health Date: 2020-06-09
Authors: Zsigmond Tamás Kincses; Dániel Veréb; Péter Faragó; Eszter Tóth; Krisztián Kocsis; Bálint Kincses; András Király; Bence Bozsik; Árpád Párdutz; Délia Szok; János Tajti; László Vécsei; Bernadett Tuka; Nikoletta Szabó Journal: Front Neurol Date: 2019-10-02 Impact factor: 4.003
Authors: M Torres-Ferrús; F Ursitti; A Alpuente; F Brunello; D Chiappino; T de Vries; S Di Marco; S Ferlisi; L Guerritore; N Gonzalez-Garcia; A Gonzalez-Martinez; D Khutorov; M Kritsilis; A Kyrou; T Makeeva; A Minguez-Olaondo; L Pilati; A Serrien; O Tsurkalenko; D Van den Abbeele; W S van Hoogstraten; C Lampl Journal: J Headache Pain Date: 2020-04-29 Impact factor: 7.277