| Literature DB >> 30525245 |
Yiping Zhu1,2, Yinzhu Bian3, Qun Zhang4, Jing Hu4, Li Li4, Mi Yang4, Hanqing Qian4, Lixia Yu4, Baorui Liu1,4, Xiaoping Qian1,4.
Abstract
Colorectal cancer (CRC) is one of the most frequently diagnosed digestive system cancer. The aim of the present study was to investigate the interactions among messenger RNAs (mRNAs), microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) in CRC to reveal the mechanisms of CRC. Differentially expressed genes (DEGs) were identified from public gene expression data sets. One thousand eighty-one common dysregulated mRNAs in two data sets were identified. Gene function analysis and protein-protein interaction network analysis indicated that these DEGs might play important roles in CRC. LINC00365 was selected through coding- noncoding network analysis and its expression was validated upregulated in 22 paired clinical samples and four CRC cell lines. A competing endogenous RNA network composed of 70 miRNAs, nine mRNAs, and LINC00365 was constructed. Eight of nine mRNAs were validated upregulated in The Cancer Genome Atlas data set. Our results suggested that LINC00365 was an oncogene in CRC and it could regulate the expression of several mRNAs through sponging miRNAs.Entities:
Keywords: bioinformatics analysis; colorectal cancer; competing endogenous RNA; long noncoding RNA; weighted gene corepression analysis
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Year: 2018 PMID： 30525245 DOI： 10.1002/jcb.28201
Source DB: PubMed Journal: J Cell Biochem ISSN： 0730-2312 Impact factor: 4.429