Literature DB >> 30525087

microRNAs: Novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma.

Silvia Ottaviani1, Leandro Castellano1,2.   

Abstract

We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways.

Entities:  

Keywords:  CSC; EMT; PDAC; TGF-β; let-7; metastasis; miR-100; miR-125b; microRNAs; stemness

Year:  2018        PMID： 30525087      PMCID： PMC6276843          DOI： 10.1080/23723556.2018.1499066

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Authors:  Ulrich Wellner; Jörg Schubert; Ulrike C Burk; Otto Schmalhofer; Feng Zhu; Annika Sonntag; Bettina Waldvogel; Corinne Vannier; Douglas Darling; Axel zur Hausen; Valerie G Brunton; Jennifer Morton; Owen Sansom; Julia Schüler; Marc P Stemmler; Christoph Herzberger; Ulrich Hopt; Tobias Keck; Simone Brabletz; Thomas Brabletz
Journal:  Nat Cell Biol       Date:  2009-11-22       Impact factor: 28.824

2.  SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.

Authors:  Sita Kugel; Carlos Sebastián; Julien Fitamant; Kenneth N Ross; Supriya K Saha; Esha Jain; Adrianne Gladden; Kshitij S Arora; Yasutaka Kato; Miguel N Rivera; Sridhar Ramaswamy; Ruslan I Sadreyev; Alon Goren; Vikram Deshpande; Nabeel Bardeesy; Raul Mostoslavsky
Journal:  Cell       Date:  2016-05-12       Impact factor: 41.582

Review 3.  Contextual determinants of TGFβ action in development, immunity and cancer.

Authors:  Charles J David; Joan Massagué
Journal:  Nat Rev Mol Cell Biol       Date:  2018-07       Impact factor: 94.444

4.  Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

Authors:  Enza Lonardo; Patrick C Hermann; Maria-Theresa Mueller; Stephan Huber; Anamaria Balic; Irene Miranda-Lorenzo; Sladjana Zagorac; Sonia Alcala; Iker Rodriguez-Arabaolaza; Juan Carlos Ramirez; Raul Torres-Ruíz; Elena Garcia; Manuel Hidalgo; David Álvaro Cebrián; Rainer Heuchel; Matthias Löhr; Frank Berger; Peter Bartenstein; Alexandra Aicher; Christopher Heeschen
Journal:  Cell Stem Cell       Date:  2011-11-04       Impact factor: 24.633

5.  MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression.

Authors:  Adam E Frampton; Leandro Castellano; Teresa Colombo; Elisa Giovannetti; Jonathan Krell; Jimmy Jacob; Loredana Pellegrino; Laura Roca-Alonso; Niccola Funel; Tamara M H Gall; Alexander De Giorgio; Filipa G Pinho; Valerio Fulci; David J Britton; Raida Ahmad; Nagy A Habib; R Charles Coombes; Victoria Harding; Thomas Knösel; Justin Stebbing; Long R Jiao
Journal:  Gastroenterology       Date:  2013-10-09       Impact factor: 22.682

6.  A miRNA signature of chemoresistant mesenchymal phenotype identifies novel molecular targets associated with advanced pancreatic cancer.

Authors:  Alakesh Bera; Kolaparthi VenkataSubbaRao; Muthu Saravanan Manoharan; Ping Hill; James W Freeman
Journal:  PLoS One       Date:  2014-09-03       Impact factor: 3.240

7.  A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells.

Authors:  Ulrike Burk; Jörg Schubert; Ulrich Wellner; Otto Schmalhofer; Elizabeth Vincan; Simone Spaderna; Thomas Brabletz
Journal:  EMBO Rep       Date:  2008-05-16       Impact factor: 8.807

8.  MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma.

Authors:  Sameer A Dhayat; Wolf Arif Mardin; Jochen Seggewiß; Anda Jana Ströse; Christiane Matuszcak; Richard Hummel; Norbert Senninger; Sören Torge Mees; Jörg Haier
Journal:  PLoS One       Date:  2015-11-25       Impact factor: 3.240

Review 9.  Genetics and biology of pancreatic ductal adenocarcinoma.

Authors:  Haoqiang Ying; Prasenjit Dey; Wantong Yao; Alec C Kimmelman; Giulio F Draetta; Anirban Maitra; Ronald A DePinho
Journal:  Genes Dev       Date:  2016-02-15       Impact factor: 11.361

10.  TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.

Authors:  Silvia Ottaviani; Justin Stebbing; Adam E Frampton; Sladjana Zagorac; Jonathan Krell; Alexander de Giorgio; Sara M Trabulo; Van T M Nguyen; Luca Magnani; Hugang Feng; Elisa Giovannetti; Niccola Funel; Thomas M Gress; Long R Jiao; Ylenia Lombardo; Nicholas R Lemoine; Christopher Heeschen; Leandro Castellano
Journal:  Nat Commun       Date:  2018-05-10       Impact factor: 14.919
  10 in total
  4 in total

1.  Anti-Proliferative and Apoptosis-Promoting Effect of microRNA-125b on Pancreatic Cancer by Targeting NEDD9 via PI3K/AKT Signaling.

Authors:  Yuzheng Xue; Yao Zhong; Tielong Wu; Yingyue Sheng; Yuanyuan Dai; Lingling Xu; Chuanqing Bao
Journal:  Cancer Manag Res       Date:  2020-08-18       Impact factor: 3.989

2.  Key LncRNAs Associated With Oxidative Stress Were Identified by GEO Database Data and Whole Blood Analysis of Intervertebral Disc Degeneration Patients.

Authors:  Xueliang Jiang; Junfei Wu; Chunhui Guo; Wenhui Song
Journal:  Front Genet       Date:  2022-07-22       Impact factor: 4.772

Review 3.  LncmiRHG-MIR100HG: A new budding star in cancer.

Authors:  Yingnan Wu; Zhenzhen Wang; Shan Yu; Dongzhe Liu; Litao Sun
Journal:  Front Oncol       Date:  2022-09-23       Impact factor: 5.738

4.  MicroRNA-1252-5p, regulated by Myb, inhibits invasion and epithelial-mesenchymal transition of pancreatic cancer cells by targeting NEDD9.

Authors:  Yuzheng Xue; Tielong Wu; Yingyue Sheng; Yao Zhong; Benshun Hu; Chuanqing Bao
Journal:  Aging (Albany NY)       Date:  2021-07-27       Impact factor: 5.682
  4 in total

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