Literature DB >> 30525086

The role of PLK1 in cancer exhibiting chromosomal instability.

Klaus Strebhardt1,2, Monika Raab1, Mourad Sanhaji1.   

Abstract

Adenomatous polyposis coli (APC) mutations cause aneuploidy and are responsible for familial adenomatous polyposis characterized by chromosomal instability. PLK1 contributes to sustain an intact spindle assembly checkpoint ensuring genomic stability. In our work using independent ApcMin/+ mouse models we revealed that PLK1 functions as tumor suppressor in APC-mutated colorectal cancers.

Entities:  

Keywords:  Adenomatous polyposis coli; Biology of malignant cells; chromosomal instability; colon cancer; polo-like kinase; protein kinase

Year:  2018        PMID： 30525086      PMCID： PMC6276849          DOI： 10.1080/23723556.2018.1485539

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation.

Authors:  J Zumbrunn; K Kinoshita; A A Hyman; I S Näthke
Journal:  Curr Biol       Date:  2001-01-09       Impact factor: 10.834

2.  Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.

Authors:  Daniela A Brito; Conly L Rieder
Journal:  Curr Biol       Date:  2006-06-20       Impact factor: 10.834

Review 3.  Causes of Chromosomal Instability.

Authors:  Holger Bastians
Journal:  Recent Results Cancer Res       Date:  2015

Review 4.  Targeting polo-like kinase 1 for cancer therapy.

Authors:  Klaus Strebhardt; Axel Ullrich
Journal:  Nat Rev Cancer       Date:  2006-04       Impact factor: 60.716

5.  Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.

Authors:  Monika Raab; Sven Kappel; Andrea Krämer; Mourad Sanhaji; Yves Matthess; Elisabeth Kurunci-Csacsko; Julia Calzada-Wack; Birgit Rathkolb; Jan Rozman; Thure Adler; Dirk H Busch; Irene Esposito; Helmut Fuchs; Valérie Gailus-Durner; Martin Klingenspor; Eckhard Wolf; Nicole Sänger; Florian Prinz; Martin Hrabě de Angelis; Jost Seibler; Juping Yuan; Martin Bergmann; Rainald Knecht; Bertolt Kreft; Klaus Strebhardt
Journal:  Nat Commun       Date:  2011-07-19       Impact factor: 14.919

6.  Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint.

Authors:  Aisling O'Connor; Stefano Maffini; Michael D Rainey; Agnieszka Kaczmarczyk; David Gaboriau; Andrea Musacchio; Corrado Santocanale
Journal:  Biol Open       Date:  2015-12-18       Impact factor: 2.422

7.  Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype.

Authors:  I Van der Auwera; S J Van Laere; S M Van den Bosch; G G Van den Eynden; B X Trinh; P A van Dam; C G Colpaert; M van Engeland; E A Van Marck; P B Vermeulen; L Y Dirix
Journal:  Br J Cancer       Date:  2008-10-07       Impact factor: 7.640

Review 8.  The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling.

Authors:  Veronica Krenn; Andrea Musacchio
Journal:  Front Oncol       Date:  2015-10-16       Impact factor: 6.244

9.  PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells.

Authors:  Monika Raab; Mourad Sanhaji; Yves Matthess; Albrecht Hörlin; Ioana Lorenz; Christina Dötsch; Nils Habbe; Oliver Waidmann; Elisabeth Kurunci-Csacsko; Ron Firestein; Sven Becker; Klaus Strebhardt
Journal:  Nat Commun       Date:  2018-03-16       Impact factor: 14.919
  9 in total
  2 in total

1.  Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy.

Authors:  Zhuangzhuang Zhang; Lijun Cheng; Jie Li; Qi Qiao; Anju Karki; Derek B Allison; Nuha Shaker; Kunyu Li; Sagar M Utturkar; Nadia M Atallah Lanman; Xiongjian Rao; Piotr Rychahou; Daheng He; Stephen F Konieczny; Chi Wang; Qing Shao; B Mark Evers; Xiaoqi Liu
Journal:  Cancer Res       Date:  2022-10-04       Impact factor: 13.312

2.  A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1.

Authors:  Mourad Sanhaji; Klaus Strebhardt; Monika Raab; Yves Matthess; Christopher A Raab; Niklas Gutfreund; Volker Dötsch; Sven Becker
Journal:  Oncogene       Date:  2021-11-10       Impact factor: 9.867
  2 in total

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