Literature DB >> 30525085

Carcinoma Cells Reprogram a Wound-healing Switch to Promote Metastasis.

Gopinath M Sundaram1, Prabha Sampath1,2,3.   

Abstract

Wound healing is a dynamic event where barrier disruption is transient and miR-198/FSTL1 molecular switch orchestrate wound re-epithelialization. However, epithelial carcinomas maintain a prolonged wound-healing phase to promote malignant transformation. Delineating the molecular mechanism we demonstrate, how epidermal growth factor (EGF) hijacks the wound-healing switch to promote metastasis of carcinoma.

Entities:  

Keywords:  EGF; biology of malignant cells and metastasis; cancer; microRNA; molecular switch

Year:  2018        PMID： 30525085      PMCID： PMC6276847          DOI： 10.1080/23723556.2018.1432255

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Tumors: wounds that do not heal-redux.

Authors:  Harold F Dvorak
Journal:  Cancer Immunol Res       Date:  2015-01       Impact factor: 11.151

Review 2.  TGFβ signaling in head and neck squamous cell carcinoma.

Authors:  R A White; S P Malkoski; X-J Wang
Journal:  Oncogene       Date:  2010-08-02       Impact factor: 9.867

3.  Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation.

Authors:  Robert A Winn; Lindsay Marek; Sun-Young Han; Karen Rodriguez; Nicole Rodriguez; Mandy Hammond; Michelle Van Scoyk; Henri Acosta; Justin Mirus; Nicholas Barry; Yvette Bren-Mattison; Terence J Van Raay; Raphael A Nemenoff; Lynn E Heasley
Journal:  J Biol Chem       Date:  2005-02-10       Impact factor: 5.157

4.  Anti-EGFR Therapy: Strategies in Head and Neck Squamous Cell Carcinoma.

Authors:  Renato J Oliveira-Silva; Ana Carolina de Carvalho; Luciano de Souza Viana; André L Carvalho; Rui M Reis
Journal:  Recent Pat Anticancer Drug Discov       Date:  2016       Impact factor: 4.169

5.  Expression of matrix metalloproteinase-9 in head and neck squamous cell carcinoma: a potential marker for prognosis.

Authors:  Henni Ruokolainen; Paavo Pääkkö; Taina Turpeenniemi-Hujanen
Journal:  Clin Cancer Res       Date:  2004-05-01       Impact factor: 12.531

6.  'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing.

Authors:  Gopinath M Sundaram; John E A Common; Felicia E Gopal; Satyanarayana Srikanta; Krishnaswamy Lakshman; Declan P Lunny; Thiam C Lim; Vivek Tanavde; E Birgitte Lane; Prabha Sampath
Journal:  Nature       Date:  2013-02-10       Impact factor: 49.962

7.  EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis.

Authors:  Gopinath M Sundaram; Hisyam M Ismail; Mohsin Bashir; Manish Muhuri; Candida Vaz; Srikanth Nama; Ghim Siong Ow; Ivshina Anna Vladimirovna; Rajkumar Ramalingam; Brian Burke; Vivek Tanavde; Vladimir Kuznetsov; E Birgitte Lane; Prabha Sampath
Journal:  J Exp Med       Date:  2017-08-21       Impact factor: 14.307

8.  The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.

Authors:  Michele Trabucchi; Paola Briata; Mariaflor Garcia-Mayoral; Astrid D Haase; Witold Filipowicz; Andres Ramos; Roberto Gherzi; Michael G Rosenfeld
Journal:  Nature       Date:  2009-05-20       Impact factor: 49.962

9.  Inhibitory signalling to the Arp2/3 complex steers cell migration.

Authors:  Irene Dang; Roman Gorelik; Carla Sousa-Blin; Emmanuel Derivery; Christophe Guérin; Joern Linkner; Maria Nemethova; Julien G Dumortier; Florence A Giger; Tamara A Chipysheva; Valeria D Ermilova; Sophie Vacher; Valérie Campanacci; Isaline Herrada; Anne-Gaelle Planson; Susan Fetics; Véronique Henriot; Violaine David; Ksenia Oguievetskaia; Goran Lakisic; Fabienne Pierre; Anika Steffen; Adeline Boyreau; Nadine Peyriéras; Klemens Rottner; Sophie Zinn-Justin; Jacqueline Cherfils; Ivan Bièche; Antonina Y Alexandrova; Nicolas B David; J Victor Small; Jan Faix; Laurent Blanchoin; Alexis Gautreau
Journal:  Nature       Date:  2013-10-16       Impact factor: 49.962

10.  Collective cell migration: Implications for wound healing and cancer invasion.

Authors:  Li Li; Yong He; Min Zhao; Jianxin Jiang
Journal:  Burns Trauma       Date:  2013-06-18
  10 in total

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