Concomitant takotsubo cardiomyopathy with PRES syndrome: A coincidence or a real heart-brain connection?

Takotsubo cardiomyopathy is a clinical entity characterized by reversible ventricular dysfunction in the absence of obstructive coronary artery disease. Posterior reversible encephalopathy syndrome is another rare clinical syndrome characterized by reversible neurological symptoms. Concomitant occurrence is increasingly reported leading to credence to hypothesis of "heart-brain connection". We present a case of a 60-year-old female admitted for neurological symptoms who developed takotsubo cardiomyopathy within 24 h of admission. <Learning objective: Two relatively new clinical entities, namely takotsubo cardiomyopathy and PRES syndrome, might have common underlying pathophysiology as they are being increasingly reported to occur at the same time and under similar circumstances. Our case helps to further validate this theory which is yet to be well established.>.