Sylvain Bise1, Nora Frulio2, Arnaud Hocquelet1, Nicolas Alberti1, Jean-Frederic Blanc3, Christophe Laurent4, Hervé Laumonier1, Charles Balabaud5, Paulette Bioulac-Sage5,6, Hervé Trillaud1,7. 1. CHU de Bordeaux, Service d'imagerie diagnostique et interventionnelle, Hôpital Haut-Lévêque, F-33604, Pessac, France. 2. CHU de Bordeaux, Service d'imagerie diagnostique et interventionnelle, Hôpital Haut-Lévêque, F-33604, Pessac, France. nora.frulio@chu-bordeaux.fr. 3. CHU de Bordeaux, Service d'hépato-gastroentérologie et oncologie digestive, Hôpital Haut-Lévêque, F-33604, Pessac, France. 4. CHU de Bordeaux, Service de Chirurgie hépato-biliaire et transplantation hépatique, Hôpital Haut-Lévêque, F-33604, Pessac, France. 5. Université de Bordeaux, INSERM, UMR 1053, F-33076, Bordeaux, France. 6. CHU de Bordeaux, Service de Pathologie, Hopital Pellegrin, F-33076, Bordeaux, France. 7. EA IMOTION (Imagerie moléculaire et thérapies innovantes en oncologie), Université de Bordeaux, F-33076, Bordeaux, France.
Abstract
OBJECTIVE: MRI is crucial for the classification of hepatocellular adenomas (HCA) into subtypes. Our objective was to review and increase MRI criteria for subtype classification and define the limits. METHODS: Pathological and radiological data of 116 HCAs were retrospectively analyzed to investigate MRI features of HCA pathological subtypes. Risk for complication was also evaluated with regard to subtype and tumor size. RESULTS: 38/43 (88%) HNF1α-mutated HCAs (H-HCAs) were discriminated by (i) fatty component (homogeneous or heterogeneous) and (ii) hypovascular pattern, with a sensitivity of 88% and a specificity of 97%. 51/58 (88%) inflammatory HCAs (IHCAs) displayed features of sinusoidal dilatation (SD) including three different patterns (global SD, atoll sign, and a new "crescent sign" corresponding to a partial peripheral rim, hyperintense on T2W and/or arterial phase with persistent delayed enhancement). Sensitivity was 88% and specificity 100%. However, some HCA remained unclassifiable by MRI: HCA remodeled by necrotic/hemorrhagic changes covering > 50% of the lesion, H-HCAs without steatosis, IHCAs without SD, β-catenin-mutated and unclassified HCAs. Regarding malignant transformation (5/116) and bleeding (24/116), none was observed when the HCA diameter was smaller than 5.2 cm and 4.2 cm, respectively. CONCLUSION: Based on the largest series evaluated until now, we identified several non-described MRI features and propose new highly sensitive and specific MRI criteria. With the addition of these new features, 88% of the two main HCA subtypes could be identified. KEY POINTS: • HNF1α-mutated hepatocellular adenomas (H-HCA) are characterized by the presence of fat and hypovascular pattern in MRI. • Inflammatory hepatocellular adenomas (I-HCA) are characterized by different patterns translating sinusoidal dilatation including the newly described crescent sign. • No MRI specific pattern was identified for β-catenin-mutated HCA (b-HCA).
OBJECTIVE: MRI is crucial for the classification of hepatocellular adenomas (HCA) into subtypes. Our objective was to review and increase MRI criteria for subtype classification and define the limits. METHODS: Pathological and radiological data of 116 HCAs were retrospectively analyzed to investigate MRI features of HCA pathological subtypes. Risk for complication was also evaluated with regard to subtype and tumor size. RESULTS: 38/43 (88%) HNF1α-mutated HCAs (H-HCAs) were discriminated by (i) fatty component (homogeneous or heterogeneous) and (ii) hypovascular pattern, with a sensitivity of 88% and a specificity of 97%. 51/58 (88%) inflammatory HCAs (IHCAs) displayed features of sinusoidal dilatation (SD) including three different patterns (global SD, atoll sign, and a new "crescent sign" corresponding to a partial peripheral rim, hyperintense on T2W and/or arterial phase with persistent delayed enhancement). Sensitivity was 88% and specificity 100%. However, some HCA remained unclassifiable by MRI: HCA remodeled by necrotic/hemorrhagic changes covering > 50% of the lesion, H-HCAs without steatosis, IHCAs without SD, β-catenin-mutated and unclassified HCAs. Regarding malignant transformation (5/116) and bleeding (24/116), none was observed when the HCA diameter was smaller than 5.2 cm and 4.2 cm, respectively. CONCLUSION: Based on the largest series evaluated until now, we identified several non-described MRI features and propose new highly sensitive and specific MRI criteria. With the addition of these new features, 88% of the two main HCA subtypes could be identified. KEY POINTS: • HNF1α-mutated hepatocellular adenomas (H-HCA) are characterized by the presence of fat and hypovascular pattern in MRI. • Inflammatory hepatocellular adenomas (I-HCA) are characterized by different patterns translating sinusoidal dilatation including the newly described crescent sign. • No MRI specific pattern was identified for β-catenin-mutated HCA (b-HCA).
Authors: Timo Alexander Auer; Uli Fehrenbach; Christian Grieser; Tobias Penzkofer; Dominik Geisel; Moritz Schmelzle; Tobias Müller; Hendrik Bläker; Daniel Seehofer; Timm Denecke Journal: Eur Radiol Date: 2020-02-21 Impact factor: 5.315