R Swart1, A E Schutte1,2, J M van Rooyen1,2, Catharina M C Mels3,4. 1. Hypertension in Africa Research Team (HART), North-West University, Private Bag X1290, Potchefstroom, 2522, South Africa. 2. Medical Research Council, Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. 3. Hypertension in Africa Research Team (HART), North-West University, Private Bag X1290, Potchefstroom, 2522, South Africa. carina.mels@nwu.ac.za. 4. Medical Research Council, Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. carina.mels@nwu.ac.za.
Abstract
PURPOSE: Despite selenium's beneficial effects in counteracting oxidative stress, inflammation, and vascular endothelial dysfunction, controversial results exist regarding the long-term associations between selenium and atherosclerosis, arterial stiffness, and hypertension. We investigated in normal and selenium-deficient groups (and the total group), whether serum selenium relates to measures of large artery structure and function over 10 years. METHODS: This longitudinal study included black adults from rural and urban areas in South Africa. Serum selenium and blood pressure were measured at baseline (N = 987). At follow-up, carotid intima media thickness (IMT), cross-sectional wall area (CSWA), carotid-femoral pulse wave velocity (c-fPWV), and blood pressure were measured (N = 718). Selenium deficiency was classified as serum levels < 8 µg/100 ml. RESULTS: In multivariable-adjusted regression analyses performed in the normal selenium group, c-fPWV after 10 years was negatively associated with baseline selenium (β = - 0.09; p = 0.016). In the normal selenium group, baseline (but not 10 years) blood pressure also associated negatively with baseline selenium (β = - 0.09; p = 0.007). Both IMT (β = 0.12; p = 0.001) and CSWA (β = 0.10; p = 0.003) after 10 years associated positively with baseline selenium in the total, normal, and selenium-deficient groups. CONCLUSION: We found a long-term vascular protective association of selenium on arterial stiffness and blood pressure in Africans with normal selenium levels, supporting the notion that selenium fulfills a vascular protective role. In contrast, we found a potential detrimental association between selenium and carotid wall thickness, particularly evident in individuals within the highest quartile of serum selenium.
PURPOSE: Despite selenium's beneficial effects in counteracting oxidative stress, inflammation, and vascular endothelial dysfunction, controversial results exist regarding the long-term associations between selenium and atherosclerosis, arterial stiffness, and hypertension. We investigated in normal and selenium-deficient groups (and the total group), whether serum selenium relates to measures of large artery structure and function over 10 years. METHODS: This longitudinal study included black adults from rural and urban areas in South Africa. Serum selenium and blood pressure were measured at baseline (N = 987). At follow-up, carotid intima media thickness (IMT), cross-sectional wall area (CSWA), carotid-femoral pulse wave velocity (c-fPWV), and blood pressure were measured (N = 718). Selenium deficiency was classified as serum levels < 8 µg/100 ml. RESULTS: In multivariable-adjusted regression analyses performed in the normal selenium group, c-fPWV after 10 years was negatively associated with baseline selenium (β = - 0.09; p = 0.016). In the normal selenium group, baseline (but not 10 years) blood pressure also associated negatively with baseline selenium (β = - 0.09; p = 0.007). Both IMT (β = 0.12; p = 0.001) and CSWA (β = 0.10; p = 0.003) after 10 years associated positively with baseline selenium in the total, normal, and selenium-deficient groups. CONCLUSION: We found a long-term vascular protective association of selenium on arterial stiffness and blood pressure in Africans with normal selenium levels, supporting the notion that selenium fulfills a vascular protective role. In contrast, we found a potential detrimental association between selenium and carotid wall thickness, particularly evident in individuals within the highest quartile of serum selenium.
Authors: D Labadarios; N P Steyn; E Maunder; U MacIntryre; G Gericke; R Swart; J Huskisson; A Dannhauser; H H Vorster; A E Nesmvuni; J H Nel Journal: Public Health Nutr Date: 2005-08 Impact factor: 4.022
Authors: A E Schutte; S Botha; C M T Fourie; L F Gafane-Matemane; R Kruger; L Lammertyn; L Malan; C M C Mels; R Schutte; W Smith; J M van Rooyen; L J Ware; H W Huisman Journal: J Hum Hypertens Date: 2017-03-23 Impact factor: 3.012
Authors: Paweł Gać; Małgorzata Poręba; Lidia Januszewska; Adam Prokopowicz; Helena Martynowicz; Grzegorz Mazur; Rafał Poręba Journal: Antioxidants (Basel) Date: 2021-01-06