Shoboo Rahmati1, Milad Azami1, Gholamreza Badfar2, Naser Parizad3, Kourosh Sayehmiri4. 1. Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran. 2. Department of Pediatrics, Behbahan Faculty of Medical Sciences, Behbahan, Iran. 3. Nursing and Midwifery Faculty, Urmia University of Medical Sciences, Urmia, Iran. 4. Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Abstract
Objective: Iron deficiency anemia is the most common cause of anemia during pregnancy. Other causes of anemia include parasitic diseases, micronutrient deficiencies, and genetic hemoglobin apathies. Maternal anemia during pregnancy is the most important public health problem. Since the relationship between maternal anemia by the months of pregnancy and premature birth has been reported differently in various studies; thus, this study aims to determine the relationship between maternal anemia during pregnancy and premature birth. Methods: This systematic review and meta-analysis article was designed based on the recommendations of PRISMA. This study was performed from 1990 to 2018. Articles extracted using related keywords such as maternal, anemia, premature birth, and pregnancy in databases, including Cochrane, Medline, Medlib, Web of Science, PubMed, Scopus, Springer, Science Direct, Embase, Google Scholar, Sid, Irandoc, Iranmedex, and Magiran. Relative risk and its confidence interval were extracted from each of the studies. The random effects model was used to combine study results and heterogeneity among the studies measured using I2 index and the data were analyzed based by using STATA software version 3.2. Results: Overall 18 studies with sample sizes of 932 090 were entered into the meta-analysis. The overall relationship between maternal anemia during pregnancy and premature birth was significant (1.56 [95% CI: 1.25-1.95]). Maternal anemia in the first trimester increases the risk of premature birth (relative risk, 1.65 [95% CI: 1.31-2.08]). But, this relationship was not significant in the second (relative risk, 1.45 [95% CI: 0.79-2.65]) and third trimester (relative risk, 1.43 [95% CI: 0.82-2.51]). Conclusion: Maternal anemia during pregnancy can be considered as a risk factor for premature birth.
Objective: Irondeficiency anemia is the most common cause of anemia during pregnancy. Other causes of anemia include parasitic diseases, micronutrient deficiencies, and genetic hemoglobin apathies. Maternal anemia during pregnancy is the most important public health problem. Since the relationship between maternal anemia by the months of pregnancy and premature birth has been reported differently in various studies; thus, this study aims to determine the relationship between maternal anemia during pregnancy and premature birth. Methods: This systematic review and meta-analysis article was designed based on the recommendations of PRISMA. This study was performed from 1990 to 2018. Articles extracted using related keywords such as maternal, anemia, premature birth, and pregnancy in databases, including Cochrane, Medline, Medlib, Web of Science, PubMed, Scopus, Springer, Science Direct, Embase, Google Scholar, Sid, Irandoc, Iranmedex, and Magiran. Relative risk and its confidence interval were extracted from each of the studies. The random effects model was used to combine study results and heterogeneity among the studies measured using I2 index and the data were analyzed based by using STATA software version 3.2. Results: Overall 18 studies with sample sizes of 932 090 were entered into the meta-analysis. The overall relationship between maternal anemia during pregnancy and premature birth was significant (1.56 [95% CI: 1.25-1.95]). Maternal anemia in the first trimester increases the risk of premature birth (relative risk, 1.65 [95% CI: 1.31-2.08]). But, this relationship was not significant in the second (relative risk, 1.45 [95% CI: 0.79-2.65]) and third trimester (relative risk, 1.43 [95% CI: 0.82-2.51]). Conclusion:Maternal anemia during pregnancy can be considered as a risk factor for premature birth.
Authors: Melissa Thoene; Matthew Van Ormer; Ana Yuil-Valdes; Taylor Bruett; Sathish Kumar Natarajan; Maheswari Mukherjee; Maranda Thompson; Tara M Nordgren; Wendy Van Lippevelde; Nina C Overby; Kwame Adu-Bonsaffoh; Ann Anderson-Berry; Corrine Hanson Journal: Placenta Date: 2019-12-05 Impact factor: 3.481
Authors: Dario E Elias; Maria R Santos; Hebe Campaña; Fernando A Poletta; Silvina L Heisecke; Juan A Gili; Julia Ratowiecki; Viviana Cosentino; Rocio Uranga; Diana Rojas Málaga; Alice Brinckmann Oliveira Netto; Ana Carolina Brusius-Facchin; César Saleme; Mónica Rittler; Hugo B Krupitzki; Jorge S Lopez Camelo; Lucas G Gimenez Journal: J Community Genet Date: 2022-08-17
Authors: H VanderMeulen; R Strauss; Y Lin; A McLeod; J Barrett; M Sholzberg; J Callum Journal: BMC Pregnancy Childbirth Date: 2020-04-06 Impact factor: 3.007