| Literature DB >> 30521086 |
Ronald C Petersen1,2, Emily S Lundt2, Terry M Therneau2, Stephen D Weigand2, David S Knopman1, Michelle M Mielke2, Rosebud O Roberts2, Val J Lowe3, Mary M Machulda4, Walter K Kremers2, Yonas E Geda5, Clifford R Jack3.
Abstract
Despite much attention to the use of biomarkers for predicting Alzheimer disease, little information is available at the individual level. We used the population-based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. For example, a 75-year-old with abnormal amyloid and cortical thinning biomarkers has about a 20% chance of cognitive impairment by age 80 years, whereas with normal biomarkers the chance is <10%. Persons with only one abnormal biomarker had similar intermediate risks. ANN NEUROL 2019;85:155-160.Entities:
Mesh:
Year: 2019 PMID: 30521086 PMCID: PMC6504922 DOI: 10.1002/ana.25388
Source DB: PubMed Journal: Ann Neurol ISSN: 0364-5134 Impact factor: 10.422