Upregulating microRNA-498 inhibits gastric cancer proliferation invasion and chemoresistance through inverse interaction of Bmi1.

This study aimed to analyze the functions of microRNA 498 (miR-498) on gastric cancer (GC) cell proliferation migration and cisplatin chemosensitivity. QTR-PCR found that miR-498 was markedly downregulated in GC cell lines and human GC tumors. It was discover that, lentivirus-mediated miR-498 overexpression inhibited cancer cell proliferations in vitro and in vivo, invasion and cisplatin chemoresistance. Bmi1 was demonstrated to be directly regulated by miR-498 in GC cell lines. Moreover, Bmi1 upregulation was found to reverse the tumor-suppressing functions of miR-498 in GC. Therefore, this study presented evidence showing miR-498 expression decreased in GC, and overexpressing miR-498 had significant inhibitory effects on GC development, likely through the inverse interaction of Bmi1.