Literature DB >> 3051857

Increased level of cerebrospinal fluid beta 2-microglobulin is related to neurologic impairment in multiple sclerosis.

O W Bjerrum1, F W Bach, I Zeeberg.   

Abstract

beta 2-microglobulin was measured in the CSF of 33 MS patients (age range 26-66 years) and compared with the 95% confidence interval determined in an age-matched reference group of 32 patients without neurologic disease. Six MS (18%) had moderately increased concentrations and this subgroup was characterized by severe neurologic impairment according to Kurtzke's expanded disability scale. Increased CSF beta 2-microglobulin concentration in MS may reflect lesion formation.

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Year:  1988        PMID： 3051857     DOI： 10.1111/j.1600-0404.1988.tb03622.x

Source DB:  PubMed          Journal:  Acta Neurol Scand        ISSN： 0001-6314            Impact factor:   3.209


  5 in total

1.  Changes in concanavalin A-reactive proteins in neurological disorders.

Authors:  L Saso; G Valentini; M G Leone; E Grippa; R Guglielmi; L Paris; G Cantore; B Silvestrini
Journal:  J Clin Lab Anal       Date:  1999       Impact factor: 2.352

2.  Cerebrospinal fluid inflammatory markers in patients with multiple sclerosis: a pilot study.

Authors:  Z Matejčíková; J Mareš; H Přikrylová Vranová; J Klosová; V Sládková; J Doláková; J Zapletalová; P Kaňovský
Journal:  J Neural Transm (Vienna)       Date:  2014-06-04       Impact factor: 3.575

3.  Interleukin-2, soluble interleukin-2-receptor, neopterin, L-tryptophan and beta 2-microglobulin levels in CSF and serum of patients with relapsing-remitting or chronic-progressive multiple sclerosis.

Authors:  M Ott; L Demisch; W Engelhardt; P A Fischer
Journal:  J Neurol       Date:  1993-12       Impact factor: 4.849

4.  Plasma proteome analysis in HTLV-1-associated myelopathy/tropical spastic paraparesis.

Authors:  Paul D W Kirk; Aviva Witkover; Alan Courtney; Alexandra M Lewin; Robin Wait; Michael P H Stumpf; Sylvia Richardson; Graham P Taylor; Charles R M Bangham
Journal:  Retrovirology       Date:  2011-10-12       Impact factor: 4.602

5.  Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes.

Authors:  Nellie A Martin; Arkadiusz Nawrocki; Viktor Molnar; Maria L Elkjaer; Eva K Thygesen; Miklos Palkovits; Peter Acs; Tobias Sejbaek; Helle H Nielsen; Zoltan Hegedus; Finn Sellebjerg; Tihamer Molnar; Eudes G V Barbosa; Nicolas Alcaraz; Ferenc Gallyas; Asa F Svenningsen; Jan Baumbach; Hans Lassmann; Martin R Larsen; Zsolt Illes
Journal:  PLoS One       Date:  2018-08-16       Impact factor: 3.240
  5 in total

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