Nusrat Homaira1,2, Nancy Briggs3, Ju-Lee Oei1,4, Lisa Hilder1,5, Barbara Bajuk6, Adam Jaffe1,2, Saad B Omer7. 1. Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine. 2. Respiratory Department, Sydney Children's Hospital, Randwick, Australia. 3. Stats Central, Mark Wainwright Analytical Centre. 4. Department of Newborn Care, Royal Hospital for Women, Randwick, Australia. 5. Centre for Big Data Research in Health, University of New South Wales, Sydney. 6. New South Wales Pregnancy and Newborn Services Network, Sydney Children's Hospitals Network, Randwick, Australia. 7. Schools of Public Health and Medicine, Emory University, Atlanta, Georgia.
Abstract
OBJECTIVE: In a population-based cohort study, we determined the association between the age at first severe respiratory syncytial virus (RSV) disease and subsequent asthma. METHODS: Incidence rates and rate ratios of the first asthma-associated hospitalization after 2 years of age in children hospitalized for RSV disease at <3 months, 3 to <6 months, 6 to <12 months, and 12-24 months of age were calculated. RESULTS: The incidence of asthma-associated hospitalization per 1000 child-years among children hospitalized for RSV disease at <3 months of age was 0.5 (95% confidence interval [CI], .2-.7); at 3 to <6 months of age, 0.9 (95% CI,.5-1.3); at 6 to <12 months of age, 2.0 (95% CI, 1.4-2.7); and at 12-24 months of age, 1.7 (95% CI, 1.0-2.5). The rate ratio of hospitalization for asthma was 2-7-fold greater among children hospitalized for RSV disease at ages ≥6 months than that among those hospitalized for RSV disease at ages 0 to <6 months. CONCLUSIONS: Although the burden of RSV disease is highest in children aged <6 months, the burden of subsequent asthma is higher in children who develop RSV disease at ages ≥6 months.
OBJECTIVE: In a population-based cohort study, we determined the association between the age at first severe respiratory syncytial virus (RSV) disease and subsequent asthma. METHODS: Incidence rates and rate ratios of the first asthma-associated hospitalization after 2 years of age in children hospitalized for RSV disease at <3 months, 3 to <6 months, 6 to <12 months, and 12-24 months of age were calculated. RESULTS: The incidence of asthma-associated hospitalization per 1000 child-years among children hospitalized for RSV disease at <3 months of age was 0.5 (95% confidence interval [CI], .2-.7); at 3 to <6 months of age, 0.9 (95% CI,.5-1.3); at 6 to <12 months of age, 2.0 (95% CI, 1.4-2.7); and at 12-24 months of age, 1.7 (95% CI, 1.0-2.5). The rate ratio of hospitalization for asthma was 2-7-fold greater among children hospitalized for RSV disease at ages ≥6 months than that among those hospitalized for RSV disease at ages 0 to <6 months. CONCLUSIONS: Although the burden of RSV disease is highest in children aged <6 months, the burden of subsequent asthma is higher in children who develop RSV disease at ages ≥6 months.
Authors: Amanda J Driscoll; S Hasan Arshad; Louis Bont; Steven M Brunwasser; Thomas Cherian; Janet A Englund; Deshayne B Fell; Laura L Hammitt; Tina V Hartert; Bruce L Innis; Ruth A Karron; Gayle E Langley; E Kim Mulholland; Patrick K Munywoki; Harish Nair; Justin R Ortiz; David A Savitz; Nienke M Scheltema; Eric A F Simões; Peter G Smith; Fred Were; Heather J Zar; Daniel R Feikin Journal: Vaccine Date: 2020-01-20 Impact factor: 3.641
Authors: Jonathan Coutts; John Fullarton; Carole Morris; ElizaBeth Grubb; Scot Buchan; Barry Rodgers-Gray; Richard Thwaites Journal: Pediatr Pulmonol Date: 2020-02-10