| Literature DB >> 30517671 |
David X Liu1, Donna L Perry1, Lisa Evans DeWald1, Yingyun Cai1, Katie R Hagen1, Timothy K Cooper1, Louis M Huzella1, Randy Hart1, Amanda Bonilla1, John G Bernbaum1, Krisztina B Janosko1, Ricky Adams1, Reed F Johnson2, Jens H Kuhn1, Matthias J Schnell3, Ian Crozier4, Peter B Jahrling1, Juan C de la Torre5.
Abstract
Lassa fever (LF) survivors develop various clinical manifestations including polyserositis, myalgia, epididymitis, and hearing loss weeks to months after recovery from acute infection. We demonstrate a systemic lymphoplasmacytic and histiocytic arteritis and periarteritis in guinea pigs more than 2 months after recovery from acute Lassa virus (LASV) infection. LASV was detected in the arterial tunica media smooth muscle cells by immunohistochemistry, in situ hybridization, and transmission electron microscopy. Our results suggest that the sequelae of LASV infection may be due to virus persistence resulting in systemic vascular damage. These findings shed light on the pathogenesis of LASV sequelae in convalescent human survivors. Published by Oxford University Press for the Infectious Diseases Society of America 2018.Entities:
Keywords: Arenaviridae; BSL-4; Lassa virus persistent infection; arenavirus; arteritis; guinea pig; mammarenavirus; periarteritis; viral hemorrhagic fever
Mesh：
Year: 2019 PMID： 30517671 PMCID： PMC6500557 DOI： 10.1093/infdis/jiy641
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226