Amanda Setti1,2, Gabriela Halpern1, Daniela Braga1,2, Rita Figueira1, Assumpto Iaconelli1,2, Edson Borges3,4. 1. Fertility Medical Group, Sao Paulo, 01401-002, Brazil. 2. Sapientiae Institute, Sao Paulo, 04503-040, Brazil. 3. Fertility Medical Group, Sao Paulo, 01401-002, Brazil. science@sapientiae.org.br. 4. Sapientiae Institute, Sao Paulo, 04503-040, Brazil. science@sapientiae.org.br.
Abstract
PURPOSE: To study the association between body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), and response to controlled ovarian stimulation, semen quality, and intracytoplasmic sperm injection (ICSI) outcomes. METHODS: This prospective observational study included data from 402 couples undergoing ICSI between January/2010-September/2016. Participants had their weight, height, waist, and hip measured before ICSI treatment. RESULTS: Gonadotropin dose was positively associated with maternal WHR. Maternal WC and WHR negatively influenced the estradiol level, number of follicles, oocytes, and mature oocytes. Maternal BMI negatively influenced oocyte yield. Semen volume was negatively influenced by male BMI. Sperm concentration was negatively associated with WHR and WHtR. Progressive sperm motility was negatively influenced by all anthropometric measures (AMs). The TMSC was negatively affected by all AM but WC. Significant differences were observed in all ICSI outcomes except pregnancy and miscarriage rates, favoring women with AM below the cut off values compared to women above the cut off. It was observed that men with AM below the cut off values showed significantly higher rates of fertilization, embryo and blastocyst development, implantation, and pregnancy than men above the cut off. When combined maternal and paternal AM were analyzed, significant differences were observed in fertilization, embryo and blastocyst development and implantation rates, favoring couples with normal BMI, WC, and WHR. CONCLUSIONS: Lower AMs have a protective effect on fertility. Awareness and counseling on how to minimize its impact in both partners could improve ICSI outcomes.
PURPOSE: To study the association between body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), and response to controlled ovarian stimulation, semen quality, and intracytoplasmic sperm injection (ICSI) outcomes. METHODS: This prospective observational study included data from 402 couples undergoing ICSI between January/2010-September/2016. Participants had their weight, height, waist, and hip measured before ICSI treatment. RESULTS: Gonadotropin dose was positively associated with maternal WHR. Maternal WC and WHR negatively influenced the estradiol level, number of follicles, oocytes, and mature oocytes. Maternal BMI negatively influenced oocyte yield. Semen volume was negatively influenced by male BMI. Sperm concentration was negatively associated with WHR and WHtR. Progressive sperm motility was negatively influenced by all anthropometric measures (AMs). The TMSC was negatively affected by all AM but WC. Significant differences were observed in all ICSI outcomes except pregnancy and miscarriage rates, favoring women with AM below the cut off values compared to women above the cut off. It was observed that men with AM below the cut off values showed significantly higher rates of fertilization, embryo and blastocyst development, implantation, and pregnancy than men above the cut off. When combined maternal and paternal AM were analyzed, significant differences were observed in fertilization, embryo and blastocyst development and implantation rates, favoring couples with normal BMI, WC, and WHR. CONCLUSIONS: Lower AMs have a protective effect on fertility. Awareness and counseling on how to minimize its impact in both partners could improve ICSI outcomes.
Authors: I S Farooqi; S A Jebb; G Langmack; E Lawrence; C H Cheetham; A M Prentice; I A Hughes; M A McCamish; S O'Rahilly Journal: N Engl J Med Date: 1999-09-16 Impact factor: 91.245
Authors: P S Duggal; K H Van Der Hoek; C R Milner; N K Ryan; D T Armstrong; D A Magoffin; R J Norman Journal: Endocrinology Date: 2000-06 Impact factor: 4.736
Authors: José Bellver; Luis P Rossal; Ernesto Bosch; Andrés Zúñiga; José T Corona; Fernando Meléndez; Emilio Gómez; Carlos Simón; José Remohí; Antonio Pellicer Journal: Fertil Steril Date: 2003-05 Impact factor: 7.329