Literature DB >> 30515526

Optimal control of diffusion processes pertaining to an opioid epidemic dynamical model with random perturbations.

Getachew K Befekadu1, Quanyan Zhu2.   

Abstract

In this paper, we consider the problem of controlling a diffusion process pertaining to an opioid epidemic dynamical model with random perturbation so as to prevent it from leaving a given bounded open domain. In particular, we assume that the random perturbation enters only through the dynamics of the susceptible group in the compartmental model of the opioid epidemic dynamics and, as a result of this, the corresponding diffusion is degenerate, for which we further assume that the associated diffusion operator is hypoelliptic, i.e., such a hypoellipticity assumption also implies that the corresponding diffusion process has a transition probability density function with strong Feller property. Here, we minimize the asymptotic exit rate of such a controlled-diffusion process from the given bounded open domain and we derive the Hamilton-Jacobi-Bellman equation for the corresponding optimal control problem, which is closely related to a nonlinear eigenvalue problem. Finally, we also prove a verification theorem that provides a sufficient condition for optimal control.

Keywords:  Diffusion processes; Epidemiology; Exit probability; Markov controls; Minimum exit rates; Optimal control problem; Prescription drug addiction; Principal eigenvalues; SIR compartmental model

Mesh:

Year:  2018        PMID: 30515526     DOI: 10.1007/s00285-018-1314-y

Source DB:  PubMed          Journal:  J Math Biol        ISSN: 0303-6812            Impact factor:   2.259


  6 in total

1.  Heroin epidemics, treatment and ODE modelling.

Authors:  Emma White; Catherine Comiskey
Journal:  Math Biosci       Date:  2006-11-07       Impact factor: 2.144

Review 2.  Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies.

Authors:  Nora D Volkow; A Thomas McLellan
Journal:  N Engl J Med       Date:  2016-03-31       Impact factor: 91.245

3.  CDC Guideline for Prescribing Opioids for Chronic Pain - United States, 2016.

Authors:  Deborah Dowell; Tamara M Haegerich; Roger Chou
Journal:  MMWR Recomm Rep       Date:  2016-03-18

4.  Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015.

Authors:  Rose A Rudd; Puja Seth; Felicita David; Lawrence Scholl
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2016-12-30       Impact factor: 17.586

5.  Reducing the Risks of Relief--The CDC Opioid-Prescribing Guideline.

Authors:  Thomas R Frieden; Debra Houry
Journal:  N Engl J Med       Date:  2016-03-15       Impact factor: 91.245

Review 6.  Prescription Opioid Analgesics Commonly Unused After Surgery: A Systematic Review.

Authors:  Mark C Bicket; Jane J Long; Peter J Pronovost; G Caleb Alexander; Christopher L Wu
Journal:  JAMA Surg       Date:  2017-11-01       Impact factor: 14.766

  6 in total

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