Literature DB >> 30514729

Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis.

Jennifer Susan Lees1,2, Fiona A Chapman2, Miles D Witham3, Alan G Jardine1,2, Patrick B Mark1,2.   

Abstract

OBJECTIVES: Vascular stiffness (VS) and vascular calcification (VC) are surrogate markers of vascular health associated with cardiovascular events. Vitamin K-dependent proteins (VKDP) are associated with VS and VC and require vitamin K for activity. We conducted a systematic review and meta-analysis of: (1) the effect of vitamin K supplementation on VS and VC and (2) association of inactive VKDP levels with incident cardiovascular disease and mortality.
METHODS: Two authors searched MEDLINE and Embase databases and Cochrane and ISRCTN registries for studies of vitamin K clinical trials that measured effects on VC, VS or VKDP and longitudinal studies assessing effect of VKDP on incident CVD or mortality. Random effects meta-analyses were performed.
RESULTS: Thirteen controlled clinical trials (n=2162) and 14 longitudinal studies (n=10 726) met prespecified inclusion criteria. Vitamin K supplementation was associated with significant reduction in VC (-9.1% (95% CI -17.7 to -0.5); p=0.04) and VKDP (desphospho-uncarboxylated matrix Gla protein; -44.7% (95% CI -65.1 to -24.3), p<0.0001) and uncarboxylated osteocalcin; -12.0% (95% CI -16.7 to -7.2), p<0.0001) compared with control, with a non-significant improvement in VS. In longitudinal studies with median follow-up of 7.8 (IQR 4.9-11.3) years, VKDP levels were associated with a combined endpoint of CVD or mortality (HR 0.45 (95% CI 0.07 to 0.83), p=0.02).
CONCLUSIONS: Supplementation with vitamin K significantly reduced VC, but not VS, compared with control. The conclusions drawn are limited by small numbers of studies with substantial heterogeneity. VKDP was associated with combined endpoint of CVD or mortality. Larger clinical trials of effect of vitamin K supplementation to improve VC, VS and long-term cardiovascular health are warranted. TRIAL REGISTRATION NUMBER: CRD42017060344. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  cardiac risk factors and prevention; coronary artery disease; meta-analysis

Mesh：

Substances：

Year:  2018        PMID： 30514729     DOI： 10.1136/heartjnl-2018-313955

Source DB:  PubMed          Journal:  Heart        ISSN： 1355-6037            Impact factor:   5.994


  23 in total

1.  Reply to: "six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2".

Authors:  Jonas W Bartstra; Pim A de Jong; Joline W J Beulens
Journal:  Eur J Nutr       Date:  2021-02-09       Impact factor: 5.614

2.  Interventions To Attenuate Vascular Calcification Progression in Chronic Kidney Disease: A Systematic Review of Clinical Trials.

Authors:  Chelsea Xu; Edward R Smith; Mark K Tiong; Irene Ruderman; Nigel D Toussaint
Journal:  J Am Soc Nephrol       Date:  2022-03-01       Impact factor: 14.978

3.  γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins.

Authors:  Zhenyu Hao; Da-Yun Jin; Xuejie Chen; Leon J Schurgers; Darrel W Stafford; Jian-Ke Tie
Journal:  Blood       Date:  2021-01-28       Impact factor: 25.476

Review 4.  Vitamin K2 Needs an RDI Separate from Vitamin K1.

Authors:  Asim Cengiz Akbulut; Angelina Pavlic; Ploingarm Petsophonsakul; Maurice Halder; Katarzyna Maresz; Rafael Kramann; Leon Schurgers
Journal:  Nutrients       Date:  2020-06-21       Impact factor: 5.717

5.  Effect of Vitamin K2 on Postural Sway in Older People Who Fall: A Randomized Controlled Trial.

Authors:  Miles D Witham; Rosemary J G Price; Margaret M Band; Michael S Hannah; Roberta L Fulton; Clare L Clarke; Peter T Donnan; Paul McNamee; Vera Cvoro; Roy L Soiza
Journal:  J Am Geriatr Soc       Date:  2019-06-18       Impact factor: 5.562

6.  Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort.

Authors:  Teresa R Haugsgjerd; Grace M Egeland; Ottar K Nygård; Kathrine J Vinknes; Gerhard Sulo; Vegard Lysne; Jannicke Igland; Grethe S Tell
Journal:  BMJ Open       Date:  2020-05-21       Impact factor: 2.692

7.  Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.

Authors:  Miles D Witham; Jennifer S Lees; Myra White; Margaret Band; Samira Bell; Donna J Chantler; Ian Ford; Roberta L Fulton; Gwen Kennedy; Roberta C Littleford; Ian V McCrea; Deborah McGlynn; Maurizio Panarelli; Maximilian R Ralston; Elaine Rutherford; Alison Severn; Nicola Thomson; Jamie P Traynor; Allan D Struthers; Kirsty Wetherall; Patrick B Mark
Journal:  J Am Soc Nephrol       Date:  2020-08-13       Impact factor: 10.121

Review 8.  Beyond Nutrient Deficiency-Opportunities to Improve Nutritional Status and Promote Health Modernizing DRIs and Supplementation Recommendations.

Authors:  Michael I McBurney; Jeffrey B Blumberg; Rebecca B Costello; Manfred Eggersdorfer; John W Erdman; William S Harris; Elizabeth J Johnson; Susan Hazels Mitmesser; Robert C Post; Deshanie Rai; Leon J Schurgers
Journal:  Nutrients       Date:  2021-05-28       Impact factor: 5.717

9.  Vitamin K for kidney transplant organ recipients: investigating vessel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial.

Authors:  Jennifer Susan Lees; Kenneth Mangion; Elaine Rutherford; Miles D Witham; Rosemary Woodward; Giles Roditi; Tracey Hopkins; Katriona Brooksbank; Alan G Jardine; Patrick B Mark
Journal:  Open Heart       Date:  2020-07

Review 10.  The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders.

Authors:  Lukas Nollet; Matthias Van Gils; Shana Verschuere; Olivier Vanakker
Journal:  Int J Mol Sci       Date:  2019-04-30       Impact factor: 5.923
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