Davidson Fróis Madureira1, Izabella Lucas De Abreu Lima2, Giselle Cabral Costa1, Elizabeth Maria Bastos Lages1, Carolina Castro Martins1, Tarcília Aparecida Da Silva3. 1. Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 2. Department of Morphology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 3. Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: tarcilia@ufmg.br.
Abstract
OBJECTIVES: The aim of this systematic review was to evaluate human gingival crevicular fluid (GCF) tumor necrosis factor-alpha (TNF-α) as a potential biomarker for diagnosis of periodontal disease (International prospective register of systematic reviews [PROSPERO] number: CRD42015020199). METHODS: An electronic search for TNF-α in human GCF was conducted until May 17, 2018. Data from systemically healthy patients with healthy periodontium or periodontal disease were incorporated. Risk bias was assessed by Newcastle-Ottawa Scale for case-control studies and Jadad scale for clinical trials. RESULTS: Twenty-six studies were included (12 case-control studies, 7 clinical trials, and 7 randomized controlled trials). Most case-control studies showed increased TNF-α concentration in GCF of patients with periodontal disease. The clinical trials and randomized controlled trials demonstrated no consistent modification of TNF-α level after periodontal intervention. CONCLUSION: The present data support the use of TNF-α in GCF as a potential biomarker for diagnosis of periodontal disease but not to monitor the healing after therapy.
OBJECTIVES: The aim of this systematic review was to evaluate human gingival crevicular fluid (GCF) tumor necrosis factor-alpha (TNF-α) as a potential biomarker for diagnosis of periodontal disease (International prospective register of systematic reviews [PROSPERO] number: CRD42015020199). METHODS: An electronic search for TNF-α in human GCF was conducted until May 17, 2018. Data from systemically healthy patients with healthy periodontium or periodontal disease were incorporated. Risk bias was assessed by Newcastle-Ottawa Scale for case-control studies and Jadad scale for clinical trials. RESULTS: Twenty-six studies were included (12 case-control studies, 7 clinical trials, and 7 randomized controlled trials). Most case-control studies showed increased TNF-α concentration in GCF of patients with periodontal disease. The clinical trials and randomized controlled trials demonstrated no consistent modification of TNF-α level after periodontal intervention. CONCLUSION: The present data support the use of TNF-α in GCF as a potential biomarker for diagnosis of periodontal disease but not to monitor the healing after therapy.
Authors: Norma Samanta Romero-Castro; Mirna Vázquez-Villamar; José Francisco Muñoz-Valle; Salvador Reyes-Fernández; Victor Othón Serna-Radilla; Samuel García-Arellano; Natividad Castro-Alarcón Journal: Odontology Date: 2019-06-18 Impact factor: 2.634
Authors: Andressa Vilas Boas Nogueira; Marjan Nokhbehsaim; Anna Damanaki; Sigrun Eick; Christian Kirschneck; Agnes Schröder; Jonathan Jantsch; James Deschner Journal: Int J Mol Sci Date: 2021-01-27 Impact factor: 5.923