Cassandra M J Wannan1,2,3,4,5, Vanessa L Cropley1,6, M Mallar Chakravarty7,8, Tamsyn E Van Rheenen1,6, Sam Mancuso9, Chad Bousman10,11,12, Ian Everall4,9,13,14,15, Patrick D McGorry2, Christos Pantelis1,4,5,9,13,15, Cali F Bartholomeusz1,2,3. 1. Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia. 2. Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia. 3. The Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia. 4. The Cooperative Research Centre for Mental Health, Melbourne, Australia. 5. North Western Mental Health, Melbourne Health, Parkville, VIC, Australia. 6. Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia. 7. Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada. 8. Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Canada. 9. Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia. 10. Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, AB, Canada. 11. Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. 12. Alberta Children's Hospital Research Institute, Calgary, AB, Canada. 13. Department of Electrical and Electronic Engineering, Centre for Neural Engineering, University of Melbourne, South Carlton, Victoria, Australia. 14. Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. 15. Florey Institute for Neuroscience & Mental Health, Parkville, VIC, Australia.
Abstract
BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophrenia, these relationships are not apparent in healthy individuals. Further, few studies have examined the role of hippocampal subfields in illness-related memory deficits, and no study has examined potential differences across varying illness stages. The current study aimed to investigate whether individuals with early and established psychosis exhibited differential relationships between visuospatial associative memory and hippocampal subfield volumes. METHODS: Measurements of visuospatial associative memory performance and grey matter volume were obtained from 52 individuals with a chronic schizophrenia-spectrum disorder, 28 youth with recent-onset psychosis, 52 older healthy controls, and 28 younger healthy controls. RESULTS: Both chronic and recent-onset patients had impaired visuospatial associative memory performance, however, only chronic patients showed hippocampal subfield volume loss. Both chronic and recent-onset patients demonstrated relationships between visuospatial associative memory performance and hippocampal subfield volumes in the CA4/dentate gyrus and the stratum that were not observed in older healthy controls. There were no group by volume interactions when chronic and recent-onset patients were compared. CONCLUSIONS: The current study extends the findings of previous studies by identifying particular hippocampal subfields, including the hippocampal stratum layers and the dentate gyrus, that appear to be related to visuospatial associative memory ability in individuals with both chronic and first-episode psychosis.
BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophrenia, these relationships are not apparent in healthy individuals. Further, few studies have examined the role of hippocampal subfields in illness-related memory deficits, and no study has examined potential differences across varying illness stages. The current study aimed to investigate whether individuals with early and established psychosis exhibited differential relationships between visuospatial associative memory and hippocampal subfield volumes. METHODS: Measurements of visuospatial associative memory performance and grey matter volume were obtained from 52 individuals with a chronic schizophrenia-spectrum disorder, 28 youth with recent-onset psychosis, 52 older healthy controls, and 28 younger healthy controls. RESULTS: Both chronic and recent-onset patients had impaired visuospatial associative memory performance, however, only chronic patients showed hippocampal subfield volume loss. Both chronic and recent-onset patients demonstrated relationships between visuospatial associative memory performance and hippocampal subfield volumes in the CA4/dentate gyrus and the stratum that were not observed in older healthy controls. There were no group by volume interactions when chronic and recent-onset patients were compared. CONCLUSIONS: The current study extends the findings of previous studies by identifying particular hippocampal subfields, including the hippocampal stratum layers and the dentate gyrus, that appear to be related to visuospatial associative memory ability in individuals with both chronic and first-episode psychosis.
Authors: Jeremy J Watts; Elisa Guma; Sofia Chavez; Rachel F Tyndale; Ruth A Ross; Sylvain Houle; Alan A Wilson; Mallar Chakravarty; Pablo M Rusjan; Romina Mizrahi Journal: Neuropsychopharmacology Date: 2022-07-29 Impact factor: 8.294
Authors: K H Christopher Choy; Jiaqi K Luo; Cassandra M J Wannan; Liliana Laskaris; Antonia Merritt; Warda T Syeda; Patrick M Sexton; Arthur Christopoulos; Christos Pantelis; Jess Nithianantharajah Journal: Transl Psychiatry Date: 2021-10-30 Impact factor: 6.222
Authors: James A Karantonis; Sean P Carruthers; Susan L Rossell; Christos Pantelis; Matthew Hughes; Cassandra Wannan; Vanessa Cropley; Tamsyn E Van Rheenen Journal: Schizophr Bull Date: 2021-10-21 Impact factor: 7.348