Mona M Okba1, Omar M Sabry1, An Matheeussen2, Essam Abdel-Sattar1. 1. Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt. 2. Laboratory for Microbiology, Parasitology & Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical & Veterinary Sciences, Antwerp University, B-2610 Wilrijk-Antwerp, Belgium.
Abstract
AIM: Antiprotozoal activity of 36 medicinal plants was evaluated. MATERIALS & METHODS: In vitro potency against Trypanosoma brucei brucei, T. b. rhodesiense, T. cruzi and Leishmania infantum beside cytotoxicity on MRC-5 fibroblasts were determined. RESULTS & CONCLUSION: Maytenus parviflora showed the highest activity against T. b. brucei (IC50 of 0.6 μg/ml) and T. b. rhodesiense (IC50 of 0.5 μg/ml) with low cytotoxicity (CC50 of 30 μg/ml). Saussurea costus and Commiphora wightii, showed pronounced potency against T. cruzi with an IC50 of 3.6 and 2.5 μg/ml, respectively. Jatropha pelargonifolia and Solanum villosum exhibited pronounced activity toward L. infantum with an IC50 of 3.2 and 2.0 μg/ml, respectively. M. parviflora, S. costus, C. wightii, J. pelargonifolia and S. villosum showed relevant selectivity.
AIM: Antiprotozoal activity of 36 medicinal plants was evaluated. MATERIALS & METHODS: In vitro potency against Trypanosoma brucei brucei, T. b. rhodesiense, T. cruzi and Leishmania infantum beside cytotoxicity on MRC-5 fibroblasts were determined. RESULTS & CONCLUSION: Maytenus parviflora showed the highest activity against T. b. brucei (IC50 of 0.6 μg/ml) and T. b. rhodesiense (IC50 of 0.5 μg/ml) with low cytotoxicity (CC50 of 30 μg/ml). Saussurea costus and Commiphora wightii, showed pronounced potency against T. cruzi with an IC50 of 3.6 and 2.5 μg/ml, respectively. Jatropha pelargonifolia and Solanum villosum exhibited pronounced activity toward L. infantum with an IC50 of 3.2 and 2.0 μg/ml, respectively. M. parviflora, S. costus, C. wightii, J. pelargonifolia and S. villosum showed relevant selectivity.