Yan-Mei Mao1, Chan-Na Zhao1, Li-Na Liu1, Qian Wu1, Yi-Lin Dan1, De-Guang Wang2, Hai-Feng Pan1. 1. Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, PR China. 2. Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, PR China.
Abstract
AIM: We performed this meta-analysis in order to evaluate circulating interleukin-8 (IL-8) levels in systemic lupus erythematosus (SLE) patients more accurately and explore its related influencing factors. METHODS: The related literature was systematically searched in PubMed, Embase and The Cochrane Library database (up to 28 March 2018). All data analysis was performed by Stata 12.0 software. RESULTS: The results showed SLE patients had a higher circulating IL-8 levels than normal controls (pooled standardized mean difference = 0.963; 95% CI: 0.416-1.511). Subgroup analyses indicated SLE patients with age <40 years, Asia group and disease duration <10 years had higher IL-8 levels. CONCLUSION: Compared with normal controls, circulating IL-8 levels in SLE patients are elevated and affected by age, region and disease duration.
AIM: We performed this meta-analysis in order to evaluate circulating interleukin-8 (IL-8) levels in systemic lupus erythematosus (SLE) patients more accurately and explore its related influencing factors. METHODS: The related literature was systematically searched in PubMed, Embase and The Cochrane Library database (up to 28 March 2018). All data analysis was performed by Stata 12.0 software. RESULTS: The results showed SLEpatients had a higher circulating IL-8 levels than normal controls (pooled standardized mean difference = 0.963; 95% CI: 0.416-1.511). Subgroup analyses indicated SLEpatients with age <40 years, Asia group and disease duration <10 years had higher IL-8 levels. CONCLUSION: Compared with normal controls, circulating IL-8 levels in SLEpatients are elevated and affected by age, region and disease duration.
Authors: Filip Bergqvist; Yvonne Sundström; Ming-Mei Shang; Iva Gunnarsson; Ingrid E Lundberg; Michael Sundström; Per-Johan Jakobsson; Louise Berg Journal: Front Pharmacol Date: 2020-05-06 Impact factor: 5.810