Yating Wang1, Li Shen1, Danyan Xu1. 1. Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Abstract
BACKGROUND:Aerobic exercise, which has been shown to have beneficial effects on plasma lipids, has been recommended as an effective measure to improve the prognosis of individuals with coronary heart disease (CHD). Apolipoprotein C3 (apoC3) is associated with hypertriglyceridemia and is therefore closely related to CHD. HYPOTHESIS: We measured apoC3 concentration change in patients with CHD before and after long-term aerobic exercise. METHODS:Thirty-eight patients with coronary heart disease were randomly assigned to a non-exercise group (19 patients) or exercise group (19 patients). Both groups received essential drugs for CHD. The non-exercise group was kept sedentary while the exercise group performed moderate-intensive aerobic exercise for 8 weeks. Lipid levels and apoC3 levels were measured on the first day and 8 weeks later. RESULTS: Exercise for 8 weeks led to a significant decrease in concentration of triglyceride and apoC3 compared with the baseline. Triglyceride concentration changes were positively associated with apoC3 level changes. CONCLUSIONS:Aerobic exercise can improve the lipid profile. It is effective in decreasing triglycerides by targeting apoC3 levels in patients with coronary heart disease.
RCT Entities:
BACKGROUND: Aerobic exercise, which has been shown to have beneficial effects on plasma lipids, has been recommended as an effective measure to improve the prognosis of individuals with coronary heart disease (CHD). Apolipoprotein C3 (apoC3) is associated with hypertriglyceridemia and is therefore closely related to CHD. HYPOTHESIS: We measured apoC3 concentration change in patients with CHD before and after long-term aerobic exercise. METHODS: Thirty-eight patients with coronary heart disease were randomly assigned to a non-exercise group (19 patients) or exercise group (19 patients). Both groups received essential drugs for CHD. The non-exercise group was kept sedentary while the exercise group performed moderate-intensive aerobic exercise for 8 weeks. Lipid levels and apoC3 levels were measured on the first day and 8 weeks later. RESULTS: Exercise for 8 weeks led to a significant decrease in concentration of triglyceride and apoC3 compared with the baseline. Triglyceride concentration changes were positively associated with apoC3 level changes. CONCLUSIONS: Aerobic exercise can improve the lipid profile. It is effective in decreasing triglycerides by targeting apoC3 levels in patients with coronary heart disease.
Authors: Michael Miller; Neil J Stone; Christie Ballantyne; Vera Bittner; Michael H Criqui; Henry N Ginsberg; Anne Carol Goldberg; William James Howard; Marc S Jacobson; Penny M Kris-Etherton; Terry A Lennie; Moshe Levi; Theodore Mazzone; Subramanian Pennathur Journal: Circulation Date: 2011-04-18 Impact factor: 29.690
Authors: Anne C Goldberg; Paul N Hopkins; Peter P Toth; Christie M Ballantyne; Daniel J Rader; Jennifer G Robinson; Stephen R Daniels; Samuel S Gidding; Sarah D de Ferranti; Matthew K Ito; Mary P McGowan; Patrick M Moriarty; William C Cromwell; Joyce L Ross; Paul E Ziajka Journal: J Clin Lipidol Date: 2011-04-12 Impact factor: 4.766
Authors: Robert J Brown; William R Lagor; Sandhya Sankaranaravanan; Tomoyuki Yasuda; Thomas Quertermous; George H Rothblat; Daniel J Rader Journal: Circ Res Date: 2010-06-17 Impact factor: 17.367
Authors: Emanuele Di Angelantonio; Nadeem Sarwar; Philip Perry; Stephen Kaptoge; Kausik K Ray; Alexander Thompson; Angela M Wood; Sarah Lewington; Naveed Sattar; Chris J Packard; Rory Collins; Simon G Thompson; John Danesh Journal: JAMA Date: 2009-11-11 Impact factor: 56.272
Authors: Michael Miller; Christopher P Cannon; Sabina A Murphy; Jie Qin; Kausik K Ray; Eugene Braunwald Journal: J Am Coll Cardiol Date: 2008-02-19 Impact factor: 24.094
Authors: Jacy Crosby; Gina M Peloso; Paul L Auer; David R Crosslin; Nathan O Stitziel; Leslie A Lange; Yingchang Lu; Zheng-zheng Tang; He Zhang; George Hindy; Nicholas Masca; Kathleen Stirrups; Stavroula Kanoni; Ron Do; Goo Jun; Youna Hu; Hyun Min Kang; Chenyi Xue; Anuj Goel; Martin Farrall; Stefano Duga; Pier Angelica Merlini; Rosanna Asselta; Domenico Girelli; Oliviero Olivieri; Nicola Martinelli; Wu Yin; Dermot Reilly; Elizabeth Speliotes; Caroline S Fox; Kristian Hveem; Oddgeir L Holmen; Majid Nikpay; Deborah N Farlow; Themistocles L Assimes; Nora Franceschini; Jennifer Robinson; Kari E North; Lisa W Martin; Mark DePristo; Namrata Gupta; Stefan A Escher; Jan-Håkan Jansson; Natalie Van Zuydam; Colin N A Palmer; Nicholas Wareham; Werner Koch; Thomas Meitinger; Annette Peters; Wolfgang Lieb; Raimund Erbel; Inke R Konig; Jochen Kruppa; Franziska Degenhardt; Omri Gottesman; Erwin P Bottinger; Christopher J O'Donnell; Bruce M Psaty; Christie M Ballantyne; Goncalo Abecasis; Jose M Ordovas; Olle Melander; Hugh Watkins; Marju Orho-Melander; Diego Ardissino; Ruth J F Loos; Ruth McPherson; Cristen J Willer; Jeanette Erdmann; Alistair S Hall; Nilesh J Samani; Panos Deloukas; Heribert Schunkert; James G Wilson; Charles Kooperberg; Stephen S Rich; Russell P Tracy; Dan-Yu Lin; David Altshuler; Stacey Gabriel; Deborah A Nickerson; Gail P Jarvik; L Adrienne Cupples; Alex P Reiner; Eric Boerwinkle; Sekar Kathiresan Journal: N Engl J Med Date: 2014-06-18 Impact factor: 91.245
Authors: Peter F Kokkinos; Charles Faselis; Jonathan Myers; Demosthenes Panagiotakos; Michael Doumas Journal: Lancet Date: 2012-11-28 Impact factor: 79.321
Authors: M John Chapman; Henry N Ginsberg; Pierre Amarenco; Felicita Andreotti; Jan Borén; Alberico L Catapano; Olivier S Descamps; Edward Fisher; Petri T Kovanen; Jan Albert Kuivenhoven; Philippe Lesnik; Luis Masana; Børge G Nordestgaard; Kausik K Ray; Zeljko Reiner; Marja-Riitta Taskinen; Lale Tokgözoglu; Anne Tybjærg-Hansen; Gerald F Watts Journal: Eur Heart J Date: 2011-04-29 Impact factor: 29.983