Literature DB >> 30509945

Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. oralis.

Truc T Tran1, Nagendra N Mishra2,3, Ravin Seepersaud4,5, Lorena Diaz1,6,7, Rafael Rios1,6,7, An Q Dinh1, Cristina Garcia-de-la-Maria8, Michael J Rybak9, Jose M Miro8, Samuel A Shelburne10, Paul M Sullam4,5, Arnold S Bayer2,3, Cesar A Arias11,6.   

Abstract

We investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (Streptococcus mitis/S. oralis subgroup) from daptomycin (DAP)-naive patients to develop DAP resistance in vitro All strains rapidly developed high-level and stable DAP resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified, i.e., CdsA (phosphatidate cytidylyltransferase) and PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3-phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. DAP interactions with the cell membrane differed in isolates with PgsA versus CdsA substitutions.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  CdsA; PgsA; Streptococcus mitiszzm321990; daptomycin resistance

Mesh：

Substances：

Year:  2019        PMID： 30509945      PMCID： PMC6355606          DOI： 10.1128/AAC.01531-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Endocarditis due to Streptococcus mitis with high-level resistance to penicillin and ceftriaxone.

Authors:  C Sabella; D Murphy; J Drummond-Webb
Journal:  JAMA       Date:  2001-05-02       Impact factor: 56.272

2.  Antimicrobial susceptibility patterns among viridans group streptococcal isolates from infective endocarditis patients from 1971 to 1986 and 1994 to 2002.

Authors:  Rajesh M Prabhu; Kerryl E Piper; Larry M Baddour; James M Steckelberg; Walter R Wilson; Robin Patel
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

3.  Scanning alanine mutagenesis of the CDP-alcohol phosphotransferase motif of Saccharomyces cerevisiae cholinephosphotransferase.

Authors:  J G Williams; C R McMaster
Journal:  J Biol Chem       Date:  1998-05-29       Impact factor: 5.157

4.  Primary structures of the wild-type and mutant alleles encoding the phosphatidylglycerophosphate synthase of Escherichia coli.

Authors:  M Usui; H Sembongi; H Matsuzaki; K Matsumoto; I Shibuya
Journal:  J Bacteriol       Date:  1994-06       Impact factor: 3.490

5.  In Vivo and in Vitro Synthesis of Phosphatidylglycerol by an Escherichia coli Cardiolipin Synthase.

Authors:  Chijun Li; Brandon K Tan; Jinshi Zhao; Ziqiang Guan
Journal:  J Biol Chem       Date:  2016-10-19       Impact factor: 5.157

6.  Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism.

Authors:  Nagendra N Mishra; Truc T Tran; Ravin Seepersaud; Cristina Garcia-de-la-Maria; Kym Faull; Alex Yoon; Richard Proctor; Jose M Miro; Michael J Rybak; Arnold S Bayer; Cesar A Arias; Paul M Sullam
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

7.  Structural basis for catalysis in a CDP-alcohol phosphotransferase.

Authors:  Giuliano Sciara; Oliver B Clarke; David Tomasek; Brian Kloss; Shantelle Tabuso; Rushelle Byfield; Raphael Cohn; Surajit Banerjee; Kanagalaghatta R Rajashankar; Vesna Slavkovic; Joseph H Graziano; Lawrence Shapiro; Filippo Mancia
Journal:  Nat Commun       Date:  2014-06-13       Impact factor: 14.919

8.  Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria.

Authors:  Hannah M Adams; Luke R Joyce; Ziqiang Guan; Ronda L Akins; Kelli L Palmer
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

9.  Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis.

Authors:  Xiuying Liu; Yan Yin; Jinjun Wu; Zhenfeng Liu
Journal:  Nat Commun       Date:  2014-06-27       Impact factor: 14.919

10.  Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum.

Authors:  Nicholas K Goldner; Christopher Bulow; Kevin Cho; Meghan Wallace; Fong-Fu Hsu; Gary J Patti; C A Burnham; Paul Schlesinger; Gautam Dantas
Journal:  mSphere       Date:  2018-08-08       Impact factor: 4.389
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  7 in total

1.  Daptomycin Dose-Ranging Evaluation with Single-Dose versus Multidose Ceftriaxone Combinations against Streptococcus mitis/oralis in an Ex Vivo Simulated Endocarditis Vegetation Model.

Authors:  Razieh Kebriaei; Seth A Rice; Kyle C Stamper; Ravin Seepersaud; Cristina Garcia-de-la-Maria; Nagendra N Mishra; Jose M Miro; Cesar A Arias; Truc T Tran; Paul M Sullam; Arnold S Bayer; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

2.  Strain-Specific Adaptations of Streptococcus mitis-oralis to Serial In Vitro Passage in Daptomycin (DAP): Genotypic and Phenotypic Characteristics.

Authors:  Nagendra N Mishra; Truc T Tran; Cesar A Arias; Ravin Seepersaud; Paul M Sullam; Arnold S Bayer
Journal:  Antibiotics (Basel)       Date:  2020-08-15

3.  Mechanistic Fingerprinting Reveals Kinetic Signatures of Resistance to Daptomycin and Host Defense Peptides in Streptococcus mitis-oralis.

Authors:  Michael R Yeaman; Liana C Chan; Nagendra N Mishra; Arnold S Bayer
Journal:  Antibiotics (Basel)       Date:  2021-04-08

4.  The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface.

Authors:  Bowei Yang; Hebang Yao; Dianfan Li; Zhenfeng Liu
Journal:  Curr Res Struct Biol       Date:  2021-11-23

5.  Development of High-Level Daptomycin Resistance in Abiotrophia and Granulicatella Species Isolates from Patients with Infective Endocarditis.

Authors:  María A Cañas; Adrian Téllez; Cristina García de la Mària; Anders Dahl; Javier García-González; Marta Hernández-Meneses; Manel Almela; Juan Ambrosioni; Carlos Falces; Eduard Quintana; Barbara Vidal; Andres Perissinotti; José M Tolosana; Elena Sandoval; Juan M Pericàs; Asunción Moreno; José M Miró
Journal:  Antimicrob Agents Chemother       Date:  2021-07-12       Impact factor: 5.191

6.  Metabolic changes associated with adaptive resistance to daptomycin in Streptococcus mitis-oralis.

Authors:  Allison Parrett; Joseph M Reed; Stewart G Gardner; Nagendra N Mishra; Arnold S Bayer; Robert Powers; Greg A Somerville
Journal:  BMC Microbiol       Date:  2020-06-15       Impact factor: 3.605

7.  Phosphatidylcholine Biosynthesis in Mitis Group Streptococci via Host Metabolite Scavenging.

Authors:  Luke R Joyce; Ziqiang Guan; Kelli L Palmer
Journal:  J Bacteriol       Date:  2019-10-21       Impact factor: 3.490
  7 in total

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