| Literature DB >> 3050941 |
D Patakas1, D Georgopoulos, H Rodini, P Christaki.
Abstract
Ten patients with chronic obstructive pulmonary disease (COPD) with normal left ventricular function were given a single dose of captopril (0.25 mg/kg). Mean systemic arterial pressure, heart rate and coronary flow to the right ventricle were reduced significantly after captopril. In contrast captopril did not cause a significant fall in pulmonary arterial pressure or pulmonary vascular resistance. We conclude that captopril fails to produce haemodynamic benefits in such hypoxic patients and that angiotensin II is not playing a significant role in maintaining pulmonary vasoconstriction.Entities:
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Year: 1988 PMID： 3050941 PMCID： PMC2428827 DOI： 10.1136/pgmj.64.749.193
Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401