Sameh Soliman1, Alshaimaa M Hamoda2, Abdel-Nasser A El-Shorbagi2, Ali A El-Keblawy3. 1. Sharjah Institute for Medical Research and College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. Electronic address: ssoliman@sharjah.ac.ae. 2. Sharjah Institute for Medical Research and College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. 3. Department of Applied Biology, University of Sharjah, Sharjah, United Arab Emirates; Research Institutes of Science and Engineering, University of Sharjah, Sharjah, United Arab Emirates.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Several natural products derived from plant sources are developed to remarkable medicines based on their traditional uses. Ziziphus, a worldwide known plant, is proven for potential cytotoxic activity. However, the plant growing at the unique hot environmental climate of UAE was never investigated. Different phytochemicals may be produced from the same plant genotype at different climates leading to variable pharmacological activities. AIM OF THE STUDY: The study was conducted in order to investigate phytochemicals in the UAE native Z. spina-christi plant and its anticancer activity. MATERIALS AND METHODS: Z. spina-christi plant were collected, dried and dissected into leaves, stems and thorns. The plant organs were subjected to comparative fractionation-based anticancer assay followed by spectroscopic analysis of a uniquely isolated compound. RESULTS: The results indicate that a novel betulin derivative (13-dehydrobetulin) isolated from plant stem exhibited substantial anticancer activity specifically against liver cancer and with wide therapeutic range. CONCLUSIONS: Growth of cytotoxic traditionally-known plant remedy at harsh environmental habitat advances its anticancer activity due to production of novel phytochemical with optimum activity and minimal toxicity. Furthermore, such approach may be a future to develop novel lead compounds with optimum activity.
ETHNOPHARMACOLOGICAL RELEVANCE: Several natural products derived from plant sources are developed to remarkable medicines based on their traditional uses. Ziziphus, a worldwide known plant, is proven for potential cytotoxic activity. However, the plant growing at the unique hot environmental climate of UAE was never investigated. Different phytochemicals may be produced from the same plant genotype at different climates leading to variable pharmacological activities. AIM OF THE STUDY: The study was conducted in order to investigate phytochemicals in the UAE native Z. spina-christi plant and its anticancer activity. MATERIALS AND METHODS:Z. spina-christi plant were collected, dried and dissected into leaves, stems and thorns. The plant organs were subjected to comparative fractionation-based anticancer assay followed by spectroscopic analysis of a uniquely isolated compound. RESULTS: The results indicate that a novel betulin derivative (13-dehydrobetulin) isolated from plant stem exhibited substantial anticancer activity specifically against liver cancer and with wide therapeutic range. CONCLUSIONS: Growth of cytotoxic traditionally-known plant remedy at harsh environmental habitat advances its anticancer activity due to production of novel phytochemical with optimum activity and minimal toxicity. Furthermore, such approach may be a future to develop novel lead compounds with optimum activity.
Authors: Mahmoud Dogara Abdulrahman; Ali Muhammad Zakariya; Harmand A Hama; Saber W Hamad; Sawsan S Al-Rawi; Sarwan W Bradosty; Ahmad H Ibrahim Journal: Adv Pharmacol Pharm Sci Date: 2022-05-29
Authors: Naglaa S Ashmawy; Eman M El-Labbad; Alshaimaa M Hamoda; Ali A El-Keblawy; Abdel-Nasser A El-Shorbagi; Kareem A Mosa; Sameh S M Soliman Journal: Plants (Basel) Date: 2022-08-15
Authors: Sameh S M Soliman; Tasneem B Alhamidi; Shifaa Abdin; Ahmed M Almehdi; Mohammad H Semreen; Razan B Alhumaidi; Sarra B Shakartalla; Mohamed Haider; Mohamed I Husseiny; Hany A Omar Journal: PLoS One Date: 2020-10-06 Impact factor: 3.240