| Literature DB >> 30508314 |
Anthonius H J Engwerda1, Rick Maassen1, Paul Tinnemans1, Hugo Meekes1, Floris P J T Rutjes1, Elias Vlieg1.
Abstract
Mefloquine is an important drug for prevention and treatment of malaria. It is commercially available as a racemic mixture, wherein only one enantiomer is active against malaria, while the other one causes severe psychotropic effects. By converting the drug into a compound that crystallizes as a racemizable racemic conglomerate, the deracemization of mefloquine into the desired enantiomer was achieved.Entities:
Keywords: chirality; deracemization; drug discovery; medicinal chemistry; synthetic methods
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Year: 2018 PMID： 30508314 DOI： 10.1002/anie.201811289
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336